Reid Hayward

Faculty

Professor

Email reid.hayward@unco.edu
Phone (970) 351-1821
Location Gunter Hall 2780
Address 501 20th St., Campus Box 39 Greeley, CO 80639

Education

Post Doctoral Fellowship, Thomas Jefferson University, Jefferson Medical College, 1996
Area of Study: Cardiovascular Pathophysiology

PhD, University of Arkansas, 1996
Area of Study: Exercise Physiology

MS, University of Kansas, 1993
Area of Study: Exercise Physiology/Physiology

BA, Harding University, 1991
Area of Study: Physical Education

Professional Experience & Affiliations

Postdoctoral Research Fellow, Thomas Jefferson University
Jefferson Medical College (1996 – 1998)

Assistant Professor, University of Northern Colorado
Sport and Exercise Science (1998 – 2004)

Associate Professor,  University of Northern Colorado
Sport and Exercise Science (2004 – 2009)

Professor, University of Northern Colorado
Sport and Exercise Science (2009 – Present)

Director, University of Northern Colorado
University of Northern Colorado Cancer Rehabilitation Institute (2013 – Present)

Research Expertise & Interests

Effects of physical activity on the immune system in preclinical cancer models and cancer patients

Immunotherapies are quickly becoming one the main ‘pillars’ of cancer treatment, yet there is limited data on how physical activity (exercise) could help or hinder cancer patients’ clinical responses to these immune-based therapies. We envision exercise as a low-cost, low-risk, potentially high-impact approach to leveraging the power of a patient’s immune system in the fight against their tumor. Much of our initial work has focused on investigating exercise’s impact on a population of immunosuppressive immune cells called Myeloid-Derived Suppressor Cells (MDSCs) in preclinical animal tumor models. Some of our early results were sufficiently promising to prompt an additional, ongoing study of MDSC populations in human cancer patients undergoing adjuvant exercise therapy at the University of Northern Colorado Cancer Rehabilitation Institute (UNCCRI).

Areas of Interest

Dr. Hayward is a Professor of Sport and Exercise Science and the Director of the University of Northern Colorado Cancer Rehabilitation Institute (www.unco.edu/unccri). The focus of our work is to improve the quality of life for cancer survivors by providing clinical exercise-based rehabilitation programs, by educating those individuals who provide exercise-based rehabilitation services, and by conducting basic and applied research that advances our understanding of cancer rehabilitation. As the Director of UNCCRI, Dr. Hayward oversees all clinical, educational, and research activities of the Institute.

Patients enrolled in our cancer rehabilitation program serve as subjects in a wide array of research studies conducted by students in our undergraduate and graduate programs at the University of Northern Colorado. Clinical research conducted at UNCCRI utilizes a multidisciplinary approach which focuses primarily on: 1) the physiological adaptations that occur in cancer survivors during exercise training, 2) identifying the exercise intensity, duration, and modality that provides the greatest benefit for cancer survivors, 3) optimizing current techniques involved with exercise assessment and prescription in cancer survivors, and 4) understanding the effects of exercise on biomarkers of prognosis and survival in cancer survivors.

In order to further understand mechanisms that may explain the beneficial effects of exercise in cancer survivors, we utilize tumor-bearing rodent models to study the effects of exercise on various physiological systems with particular interests in the cardiovascular, muscular, and immune systems. Our facilities are equipped with modern wet laboratory equipment necessary to conduct an array of biological experiments including protein analyses, spectrophotometry, and flow cytometry. Our research focuses primarily on: 1) understanding mechanisms by which exercise attenuates chemotherapy-induced toxicities associated with standard cancer treatments such as anthracyclines, 2) the impact of cancer on cardiac, muscular, and immune function and how exercise can mitigate their deleterious effect, 3) how exercise can be used in the rehabilitation of cancer/cachexia-induced cardiac dysfunction, and 4) the interaction of cancer, chemotherapy, and exercise on clinical biomarkers of cancer prognosis and survival.

Publications

  • Rasé VJ, Hayward R, Haughian JM, Pullen NA. T(h)17, T(h)22, and Myeloid-Derived Suppressor Cell Population Dynamics and Response to IL-6 in 4T1 Mammary Carcinoma. Int J Mol Sci. 2022 Sep 7;23(18). https://doi.org/10.3390/ijms231810299. PubMed PMID: 36142210; PubMed Central PMCID: PMC9498998.
  • Wood NR, Garritson J, Mathias A, Haughian JM, Hayward R. Moderate Intensity Endurance and Resistance Exercise Attenuates Cachexia in Tumor-bearing Mice. Anticancer Res. 2022 Jan;42(1):397-405. https://doi.org/10.21873/anticanres.15498. PubMed PMID: 34969750.
  • Olson TL, Dames KD, Smith JD, Hayward R. Relationships between Physiological and Self-Reported Assessment of Cancer-Related Fatigue. Int J Exerc Sci. 2022;15(3):177-190. https://doi.org/10.70252/SSZO6869. eCollection 2022. PubMed PMID: 36895434; PubMed Central PMCID: PMC9987435.
  • Harman N, Lazio M, Hayward R. Exercise training-induced adaptations in lung cancer patients who have undergone a lobectomy. Exp Gerontol. 2021 Nov;155:111587. https://doi.org/10.1016/j.exger.2021.111587. Epub 2021 Oct 9. PubMed PMID: 34637950.
  • Smoak P, Harman N, Flores V, Kisiolek J, Pullen NA, Lisano J, Hayward R, Stewart LK. Kefir Is a Viable Exercise Recovery Beverage for Cancer Survivors Enrolled in a Structured Exercise Program. Med Sci Sports Exerc. 2021 Oct 1;53(10):2045-2053. https://doi.org/10.1249/MSS.0000000000002690. PubMed PMID: 34519716.
  • Murphy SP, Hayward R, Smith JD. Exercise training improves postural steadiness in cancer survivors undergoing chemotherapy. Gait Posture. 2021 Jun;87:136-142. https://doi.org/10.1016/j.gaitpost.2021.04.013. Epub 2021 Apr 20. PubMed PMID: 33915436.
  • Smoak P, Flores V, Harman N, Lisano J, Hayward R, Stewart LK. Structured Exercise in Cancer Survivors: Is it Enough for Neural, Mental Health and Well-being?. Int J Exerc Sci. 2021;14(3):162-176. https://doi.org/10.70252/AJQK9649. eCollection 2021. PubMed PMID: 34055157; PubMed Central PMCID: PMC8136549.
  • Garritson J, Krynski L, Haverbeck L, Haughian JM, Pullen NA, Hayward R. Physical activity delays accumulation of immunosuppressive myeloid-derived suppressor cells. PLoS One. 2020;15(6):e0234548. https://doi.org/10.1371/journal.pone.0234548. eCollection 2020. PubMed PMID: 32542046; PubMed Central PMCID: PMC7295224.
  • Peterson BM, Shackelford DYK, Brown JM, Brennecke AP, Hayward R. Effects of Aerobic and Flexibility Training on Physiological and Psychosocial Function in a Patient with Anaplastic Oligodendroglioma: A Case Report. J Rehabil Med Clin Commun. 2020;3:1000032. https://doi.org/10.2340/20030711-1000032. eCollection 2020. PubMed PMID: 33884134; PubMed Central PMCID: PMC8008718.
  • Hayward R, Brown J, Shackelford D, Harman N, Lazio M. Enhancing the Utility and Reporting of Real-World Exercise Programs in Cancer Care. Translational Journal of the American College of Sports Medicine. 2019 September; 4(18):194-196. https://doi.org/10.1249/TJX.0000000000000112.
  • Christensen MA, Smoak P, Lisano JK, Hayward R, Coronado C, Kage K, Shackelford D, Stewart LK. Cardiorespiratory fitness, visceral fat, and body fat, but not dietary inflammatory index, are related to C-reactive protein in cancer survivors. Nutr Health. 2019 Sep;25(3):195-202. https://doi.org/10.1177/0260106019841840. Epub 2019 Apr 16. PubMed PMID: 30991889.
  • Brown J, Shackelford D, Hipp M, Hayward R. Evaluation of an Exercise-Based Phase Program as Part of a Standard Care Model for Cancer Survivors. Translational Journal of the American College of Sports Medicine. 2019 April; 4(7):45-54. https://doi.org/10.1249/TJX.0000000000000082.
  • Stewart LK, Smoak P, Hydock DS, Hayward R, O’Brien K, Lisano JK, Boeneke C, Christensen M, Mathias A. Milk and kefir maintain aspects of health during doxorubicin treatment in rats. J Dairy Sci. 2019 Mar;102(3):1910-1917. https://doi.org/10.3168/jds.2018-15576. Epub 2019 Jan 17. PubMed PMID: 30660421.
  • Schumacher AN, Shackelford DYK, Brown JM, Hayward R. Validation of the 6-min Walk Test for Predicting Peak V˙O2 in Cancer Survivors. Med Sci Sports Exerc. 2019 Feb;51(2):271-277. https://doi.org/10.1249/MSS.0000000000001790. PubMed PMID: 30239495.
  • Hall SE, Smuder AJ, Hayward R. Effects of Calorie Restriction and Voluntary Exercise on Doxorubicin-Induced Cardiotoxicity. Integr Cancer Ther. 2019 Jan-Dec;18:1534735419843999. https://doi.org/10.1177/1534735419843999. PubMed PMID: 30999765; PubMed Central PMCID: PMC6475835.
  • Pfannenstiel K, Hayward R. Effects of Resistance Exercise Training on Doxorubicin-Induced Cardiotoxicity. J Cardiovasc Pharmacol. 2018 Jun;71(6):332-339. https://doi.org/10.1097/FJC.0000000000000574. PubMed PMID: 29521673.
  • Repka CP, Hayward R. Effects of an Exercise Intervention on Cancer-Related Fatigue and Its Relationship to Markers of Oxidative Stress. Integr Cancer Ther. 2018 Jun;17(2):503-510. https://doi.org/10.1177/1534735418766402. Epub 2018 Apr 12. PubMed PMID: 29649913; PubMed Central PMCID: PMC6041925.
  • Parry TL, Hayward R. Exercise Protects against Cancer-induced Cardiac Cachexia. Med Sci Sports Exerc. 2018 Jun;50(6):1169-1176. https://doi.org/10.1249/MSS.0000000000001544. PubMed PMID: 29315166.
  • Peterson BM, Johnson C, Case KR, Shackelford DYK, Brown JM, Lalonde TL, Hayward R. Feasibility of a combined aerobic and cognitive training intervention on cognitive function in cancer survivors: a pilot investigation. Pilot Feasibility Stud. 2018;4:50. https://doi.org/10.1186/s40814-018-0242-3. eCollection 2018. PubMed PMID: 29468085; PubMed Central PMCID: PMC5816373.
  • Peterson BM, Brown JM, Shackelford DY, Olson T, Lalonde TL, Hayward R. Implications of Physical Activity History on Initial Physiological and Psychosocial Variables in Cancer Survivors Entering a Cancer Rehabilitation Program. Journal of Clinical Exercise Physiology. 2018.
  • Dunne RF, Mustian KM, Garcia JM, Dale W, Hayward R, Roussel B, Buschmann MM, Caan BJ, Cole CL, Fleming FJ, Chakkalakal JV, Linehan DC, Hezel AF, Mohile SG. Research priorities in cancer cachexia: The University of Rochester Cancer Center NCI Community Oncology Research Program Research Base Symposium on Cancer Cachexia and Sarcopenia. Curr Opin Support Palliat Care. 2017 Dec;11(4):278-286. https://doi.org/10.1097/SPC.0000000000000301. Review. PubMed PMID: 28957880; PubMed Central PMCID: PMC5658778.
  • O’Brien K, Boeneke C, Prinyawiwatkul W, Lisano J, Shackelford D, Reeves K, Christensen M, Hayward R, Ordonez KC, Stewart LK. Short communication: Sensory analysis of a kefir product designed for active cancer survivors. J Dairy Sci. 2017 Jun;100(6):4349-4353. https://doi.org/10.3168/jds.2016-12320. Epub 2017 Apr 21. PubMed PMID: 28434726.
  • Vin-Raviv N, Akinyemiju T, Meng Q, Sakhuja S, Hayward R. Marijuana use and inpatient outcomes among hospitalized patients: analysis of the nationwide inpatient sample database. Cancer Med. 2017 Jan;6(1):320-329. https://doi.org/10.1002/cam4.968. Epub 2016 Nov 28. PubMed PMID: 27891823; PubMed Central PMCID: PMC5269570.
  • Shackelford DY, Brown JM, Peterson BM, Schaffer J, Hayward R. Validation of the University of Northern Colorado Cancer Rehabilitation Institute Treadmill Protocol. International Journal of Physical Medicine and Rehabilitation. 2017; 5:437.
  • Quinn CJ, Burns PD, Gibson NM, Bashore A, Hayward R, Hydock DS. Effects of Chronic Endurance Exercise on Doxorubicin-Induced Thymic Damage. Integr Cancer Ther. 2016 Dec;15(4):535-541. https://doi.org/10.1177/1534735415617014. Epub 2015 Nov 20. PubMed PMID: 26590123; PubMed Central PMCID: PMC5739152.
  • Bredahl EC, Pfannenstiel KB, Quinn CJ, Hayward R, Hydock DS. Effects of Exercise on Doxorubicin-Induced Skeletal Muscle Dysfunction. Med Sci Sports Exerc. 2016 Aug;48(8):1468-73. https://doi.org/10.1249/MSS.0000000000000926. PubMed PMID: 27015384.
  • Repka CP, Hayward R. Oxidative Stress and Fitness Changes in Cancer Patients after Exercise Training. Med Sci Sports Exerc. 2016 Apr;48(4):607-14. https://doi.org/10.1249/MSS.0000000000000821. PubMed PMID: 26587845; PubMed Central PMCID: PMC4979000.
  • Lien CY, Jensen BT, Hydock DS, Hayward R. Short-term exercise training attenuates acute doxorubicin cardiotoxicity. J Physiol Biochem. 2015 Dec;71(4):669-78. https://doi.org/10.1007/s13105-015-0432-x. Epub 2015 Sep 24. PubMed PMID: 26403766.
  • Parry TL, Hayward R. Exercise training does not affect anthracycline antitumor efficacy while attenuating cardiac dysfunction. Am J Physiol Regul Integr Comp Physiol. 2015 Sep 15;309(6):R675-83. https://doi.org/10.1152/ajpregu.00185.2015. Epub 2015 Aug 5. PubMed PMID: 26246505.
  • Schneider CM, Repka CP, Brown JM, Lalonde TL, Dallow KT, Barlow CE, Hayward R. Demonstration of the need for cardiovascular and pulmonary normative data for cancer survivors. Int J Sports Med. 2014 Dec;35(13):1134-7. https://doi.org/10.1055/s-0034-1375691. Epub 2014 Jul 4. PubMed PMID: 24995960.
  • Repka CP, Peterson BM, Brown JM, Lalonde TL, Schneider CM, Hayward R. Cancer type does not affect exercise-mediated improvements in cardiorespiratory function and fatigue. Integr Cancer Ther. 2014 Nov;13(6):473-81. https://doi.org/10.1177/1534735414547108. Epub 2014 Aug 22. PubMed PMID: 25148839.
  • Parry TL, Hydock DS, Jensen BT, Lien CY, Schneider CM, Hayward R. Endurance exercise attenuates cardiotoxicity induced by androgen deprivation and doxorubicin. Can J Physiol Pharmacol. 2014 May;92(5):356-62. https://doi.org/10.1139/cjpp-2013-0294. Epub 2014 Mar 10. PubMed PMID: 24784469.
  • Gibson NM, Quinn CJ, Pfannenstiel KB, Hydock DS, Hayward R. Effects of age on multidrug resistance protein expression and doxorubicin accumulation in cardiac and skeletal muscle. Xenobiotica. 2014 May;44(5):472-9. https://doi.org/10.3109/00498254.2013.846489. Epub 2013 Oct 18. PubMed PMID: 24138210.
  • Hydock DS, Parry TL, Wymore JD, Iwaniec UT, Turner RT, Schneider CM, Hayward R. Effects of treadmill training on combined goserelin acetate and doxorubicin-induced osteopenia in female rats. J Musculoskelet Neuronal Interact. 2014 Mar;14(1):10-8. PubMed PMID: 24583536.
  • Gibson NM, Greufe SE, Hydock DS, Hayward R. Doxorubicin-induced vascular dysfunction and its attenuation by exercise preconditioning. J Cardiovasc Pharmacol. 2013 Oct;62(4):355-60. https://doi.org/10.1097/FJC.0b013e31829c9993. PubMed PMID: 23719093.
  • Jensen BT, Lien CY, Hydock DS, Schneider CM, Hayward R. Exercise mitigates cardiac doxorubicin accumulation and preserves function in the rat. J Cardiovasc Pharmacol. 2013 Sep;62(3):263-9. https://doi.org/10.1097/FJC.0b013e3182982ce0. PubMed PMID: 23644988.
  • Hayward R, Hydock D, Gibson N, Greufe S, Bredahl E, Parry T. Tissue retention of doxorubicin and its effects on cardiac, smooth, and skeletal muscle function. J Physiol Biochem. 2013 Jun;69(2):177-87. https://doi.org/10.1007/s13105-012-0200-0. Epub 2012 Aug 14. PubMed PMID: 22890792.
  • Hydock DS, Lien CY, Jensen BT, Schneider CM, Hayward R. Switching to a low-fat diet attenuates the intensified doxorubicin cardiotoxicity associated with high-fat feeding. Cancer Chemother Pharmacol. 2013 Jun;71(6):1551-60. https://doi.org/10.1007/s00280-013-2154-5. Epub 2013 Apr 9. PubMed PMID: 23568281.
  • Hayward R, Iwaniec UT, Turner RT, Lien CY, Jensen BT, Hydock DS, Schneider CM. Voluntary wheel running in growing rats does not protect against doxorubicin-induced osteopenia. J Pediatr Hematol Oncol. 2013 May;35(4):e144-8. https://doi.org/10.1097/MPH.0b013e318279b1fb. PubMed PMID: 23211689.
  • Schneider CM, Hayward R. Cancer Rehabilitation and Cancer-Related Fatigue. Journal of Clinical Exercise Physiology. 2013; 2:1-7.
  • Hydock DS, Lien CY, Jensen BT, Parry TL, Schneider CM, Hayward R. Rehabilitative exercise in a rat model of doxorubicin cardiotoxicity. Exp Biol Med (Maywood). 2012 Dec;237(12):1483-92. https://doi.org/10.1258/ebm.2012.012137. PubMed PMID: 23354407.
  • Hayward R, Lien CY, Jensen BT, Hydock DS, Schneider CM. Exercise training mitigates anthracycline-induced chronic cardiotoxicity in a juvenile rat model. Pediatr Blood Cancer. 2012 Jul 15;59(1):149-54. https://doi.org/10.1002/pbc.23392. Epub 2011 Nov 2. PubMed PMID: 22052855.
  • Hydock DS, Parry TL, Jensen BT, Lien CY, Schneider CM, Hayward R. Effects of endurance training on combined goserelin acetate and doxorubicin treatment-induced cardiac dysfunction. Cancer Chemother Pharmacol. 2011 Sep;68(3):685-92. https://doi.org/10.1007/s00280-010-1523-6. Epub 2010 Dec 5. PubMed PMID: 21132497.
  • Hayward R, Lien CY. Echocardiographic evaluation of cardiac structure and function during exercise training in the developing Sprague-Dawley rat. J Am Assoc Lab Anim Sci. 2011 Jul;50(4):454-61. PubMed PMID: 21838971; PubMed Central PMCID: PMC3148638.
  • Hydock DS, Lien CY, Jensen BT, Schneider CM, Hayward R. Characterization of the effect of in vivo doxorubicin treatment on skeletal muscle function in the rat. Anticancer Res. 2011 Jun;31(6):2023-8. PubMed PMID: 21737618.
  • Hydock DS, Lien CY, Jensen BT, Schneider CM, Hayward R. Exercise preconditioning provides long-term protection against early chronic doxorubicin cardiotoxicity. Integr Cancer Ther. 2011 Mar;10(1):47-57. https://doi.org/10.1177/1534735410392577. Epub 2011 Mar 7. PubMed PMID: 21382960.
  • Sprod LK, Hsieh CC, Hayward R, Schneider CM. Three versus six months of exercise training in breast cancer survivors. Breast Cancer Res Treat. 2010 Jun;121(2):413-9. https://doi.org/10.1007/s10549-010-0913-0. Epub 2010 May 5. PubMed PMID: 20443054; PubMed Central PMCID: PMC3025531.
  • Hydock DS, Wonders KY, Schneider CM, Hayward R. Voluntary wheel running in rats receiving doxorubicin: effects on running activity and cardiac myosin heavy chain. Anticancer Res. 2009 Nov;29(11):4401-7. PubMed PMID: 20032385.
  • Wonders KY, Hydock DS, Greufe S, Schneider CM, Hayward R. Endurance exercise training preserves cardiac function in rats receiving doxorubicin and the HER-2 inhibitor GW2974. Cancer Chemother Pharmacol. 2009 Nov;64(6):1105-13. https://doi.org/10.1007/s00280-009-0967-z. Epub 2009 Apr 8. PubMed PMID: 19352663.
  • Hydock DS, Lien CY, Hayward R. Anandamide preserves cardiac function and geometry in an acute doxorubicin cardiotoxicity rat model. J Cardiovasc Pharmacol Ther. 2009 Mar;14(1):59-67. https://doi.org/10.1177/1074248408329449. Epub 2009 Jan 7. PubMed PMID: 19129423.
  • Hydock DS, Iwaniec UT, Turner RT, Lien CY, Jensen BT, Parry TL, Schneider CM, Hayward R. Effects of voluntary wheel running on goserelin acetate-induced bone degeneration. Pathophysiology. 2008 Dec;15(4):253-9. https://doi.org/10.1016/j.pathophys.2008.10.002. PubMed PMID: 19041803.
  • Hsieh CC, Sprod LK, Hydock DS, Carter SD, Hayward R, Schneider CM. Effects of a supervised exercise intervention on recovery from treatment regimens in breast cancer survivors. Oncol Nurs Forum. 2008 Nov;35(6):909-15. https://doi.org/10.1188/08.ONF.909-915. PubMed PMID: 18980921; PubMed Central PMCID: PMC3040031.
  • Wonders KY, Hydock DS, Schneider CM, Hayward R. Acute exercise protects against doxorubicin cardiotoxicity. Integr Cancer Ther. 2008 Sep;7(3):147-54. https://doi.org/10.1177/1534735408322848. PubMed PMID: 18815146.
  • Hydock DS, Lien CY, Schneider CM, Hayward R. Exercise preconditioning protects against doxorubicin-induced cardiac dysfunction. Med Sci Sports Exerc. 2008 May;40(5):808-17. https://doi.org/10.1249/MSS.0b013e318163744a. PubMed PMID: 18408619.
  • Hydock DS, Lien CY, Schneider CM, Hayward R. Effects of voluntary wheel running on cardiac function and myosin heavy chain in chemically gonadectomized rats. Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3254-64. https://doi.org/10.1152/ajpheart.00801.2007. Epub 2007 Sep 28. PubMed PMID: 17906105.
  • Schneider CM, Hsieh CC, Sprod LK, Carter SD, Hayward R. Cancer treatment-induced alterations in muscular fitness and quality of life: the role of exercise training. Ann Oncol. 2007 Dec;18(12):1957-62. https://doi.org/10.1093/annonc/mdm364. Epub 2007 Sep 5. PubMed PMID: 17804476.
  • Wonders KY, Hydock DS, Hayward R. Time-course of changes in cardiac function during recovery after acute exercise. Appl Physiol Nutr Metab. 2007 Dec;32(6):1164-9. https://doi.org/10.1139/H07-127. PubMed PMID: 18059591.
  • Schneider CM, Hsieh CC, Sprod LK, Carter SD, Hayward R. Exercise training manages cardiopulmonary function and fatigue during and following cancer treatment in male cancer survivors. Integr Cancer Ther. 2007 Sep;6(3):235-41. https://doi.org/10.1177/1534735407305871. PubMed PMID: 17761636.
  • Schneider CM, Hsieh CC, Sprod LK, Carter SD, Hayward R. Effects of supervised exercise training on cardiopulmonary function and fatigue in breast cancer survivors during and after treatment. Cancer. 2007 Aug 15;110(4):918-25. https://doi.org/10.1002/cncr.22862. PubMed PMID: 17582616.
  • Hayward R, Hydock DS. Doxorubicin cardiotoxicity in the rat: an in vivo characterization. J Am Assoc Lab Anim Sci. 2007 Jul;46(4):20-32. PubMed PMID: 17645292.
  • Hydock DS, Wonders KY, Schneider CM, Hayward R. Androgen deprivation therapy and cardiac function: effects of endurance training. Prostate Cancer Prostatic Dis. 2006;9(4):392-8. https://doi.org/10.1038/sj.pcan.4500890. Epub 2006 Jun 20. PubMed PMID: 16786038.
  • Chicco AJ, Schneider CM, Hayward R. Exercise training attenuates acute doxorubicin-induced cardiac dysfunction. J Cardiovasc Pharmacol. 2006 Feb;47(2):182-9. https://doi.org/10.1097/01.fjc.0000199682.43448.2d. PubMed PMID: 16495754.
  • Chicco AJ, Hydock DS, Schneider CM, Hayward R. Low-intensity exercise training during doxorubicin treatment protects against cardiotoxicity. J Appl Physiol (1985). 2006 Feb;100(2):519-27. https://doi.org/10.1152/japplphysiol.00148.2005. Epub 2005 Oct 6. PubMed PMID: 16210442.
  • Chicco A, Turner R, McCarty H, Westerlind K, Hayward R. Resistance exercise training reduces ethanol-induced oxidative stress. European Journal of Cardiovascular and Pulmonary Rehabilitation. 2006; 13:74-79.
  • Chicco AJ, Schneider CM, Hayward R. Voluntary exercise protects against acute doxorubicin cardiotoxicity in the isolated perfused rat heart. Am J Physiol Regul Integr Comp Physiol. 2005 Aug;289(2):R424-R431. https://doi.org/10.1152/ajpregu.00636.2004. Epub 2005 Apr 21. PubMed PMID: 15845878.
  • Hayward R, Ruangthai R, Schneider CM, Hyslop RM, Strange R, Westerlind KC. Training enhances vascular relaxation after chemotherapy-induced vasoconstriction. Med Sci Sports Exerc. 2004 Mar;36(3):428-34. https://doi.org/10.1249/01.mss.0000117130.91142.38. PubMed PMID: 15076784.
  • Hayward R, Hutcheson KA, Schneider CM. Influence of acute resistance exercise on cardiac biomarkers in untrained women. J Emerg Med. 2003 Nov;25(4):351-6. https://doi.org/10.1016/s0736-4679(03)00239-7. PubMed PMID: 14654172.
  • Hayward R, Ruangthai R, Karnilaw P, Chicco A, Strange R, McCarty H, Westerlind KC. Attenuation of homocysteine-induced endothelial dysfunction by exercise training. Pathophysiology. 2003 Sep;9(4):207-214. https://doi.org/10.1016/s0928-4680(03)00023-3. PubMed PMID: 14567923.
  • Carter SD, Drum SN, Hayward R, Schneider CM. A case study: prescriptive exercise intervention after bilateral mastectomies. Integr Cancer Ther. 2003 Mar;2(1):34-8. https://doi.org/10.1177/1534735403251168. PubMed PMID: 12941166.
  • Hayward R, Lefer AM. Acute mesenteric ischemia and reperfusion: protective effects of recombinant soluble P-selectin glycoprotein ligand-1. Shock. 1999 Sep;12(3):201-7. PubMed PMID: 10485598.
  • Lefer AM, Campbell B, Shin YK, Scalia R, Hayward R, Lefer DJ. Simvastatin preserves the ischemic-reperfused myocardium in normocholesterolemic rat hearts. Circulation. 1999 Jul 13;100(2):178-84. https://doi.org/10.1161/01.cir.100.2.178. PubMed PMID: 10402448.
  • Hayward R, Lefer AM. Administration of polymerized bovine hemoglobin improves survival in a rat model of traumatic shock. Methods Find Exp Clin Pharmacol. 1999 Jul-Aug;21(6):427-33. https://doi.org/10.1358/mf.1999.21.6.541924. PubMed PMID: 10445236.
  • Hayward R, Ferrington DA, Kochanowski LA, Miller LM, Jaworsky GM, Schneider CM. Effects of dietary protein on enzyme activity following exercise-induced muscle injury. Med Sci Sports Exerc. 1999 Mar;31(3):414-20. https://doi.org/10.1097/00005768-199903000-00010. PubMed PMID: 10188746.
  • Scalia R, Hayward R, Armstead VE, Minchenko AG, Lefer AM. Effect of recombinant soluble P-selectin glycoprotein ligand-1 on leukocyte-endothelium interaction in vivo. Role in rat traumatic shock. Circ Res. 1999 Jan 8-22;84(1):93-102. https://doi.org/10.1161/01.res.84.1.93. PubMed PMID: 9915778.
  • Hayward R, Campbell B, Shin YK, Scalia R, Lefer AM. Recombinant soluble P-selectin glycoprotein ligand-1 protects against myocardial ischemic reperfusion injury in cats. Cardiovasc Res. 1999 Jan;41(1):65-76. https://doi.org/10.1016/s0008-6363(98)00266-1. PubMed PMID: 10325954.
  • Hayward R, Lefer AM. Time course of endothelial-neutrophil interaction in splanchnic artery ischemia-reperfusion. Am J Physiol. 1998 Dec;275(6):H2080-6. https://doi.org/10.1152/ajpheart.1998.275.6.H2080. PubMed PMID: 9843807.
  • Nossuli TO, Hayward R, Jensen D, Scalia R, Lefer AM. Mechanisms of cardioprotection by peroxynitrite in myocardial ischemia and reperfusion injury. Am J Physiol. 1998 Aug;275(2):H509-19. https://doi.org/10.1152/ajpheart.1998.275.2.H509. PubMed PMID: 9683439.\
  • Hayward R, Scalia R, Hopper B, Appel JZ 3rd, Lefer AM. Cellular mechanisms of heparinase III protection in rat traumatic shock. Am J Physiol. 1998 Jul;275(1):H23-30. https://doi.org/10.1152/ajpheart.1998.275.1.H23. PubMed PMID: 9688892.
  • Hayward R, Balog JM, Schneider CM. Response of serum indicators of myocardial infarction following exercise-induced muscle injury. Am J Emerg Med. 1998 Mar;16(2):107-13. https://doi.org/10.1016/s0735-6757(98)90023-7. PubMed PMID: 9517680.
  • Hayward R, Lefer AM. L-arginine attenuates endothelial dysfunction and prolongs survival in rats subjected to traumatic shock. Endothelium. 1998;6(1):71-9. https://doi.org/10.3109/10623329809053406. PubMed PMID: 9832334.
  • Hayward R, Nossuli TO, Scalia R, Lefer AM. Time course of intercellular adhesion molecule-1 upregulation following endotoxin administration. Sepsis. 1998; 2:171-175.
  • Hayward R, Dennehy CA, Rodearmel SJ, Schneider CM. Serum creatine kinase, CK-MB, and perceived soreness following eccentric exercise in oral contraceptive users. Journal of Sports Medicine, Training, and Rehabilitation. 1998; 8:193-207.
  • Hayward R, Lefer AM. Vasculoprotective effects of LEX-032, a novel recombinant serpin, during splanchnic ischemia and reperfusion. Cardiovascular Pathobiology. 1998; 2:191-198.
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