Greg DeKrey

Post Doc, Colorado State University, 2001.
Area of Study: Molecular Toxicology

Post Doc, Colorado State University, 2000.
Area of Study: Immunoparasitology

Post Doc, Oregon State University, 1995.
Area of Study: Cell Biology

PhD, Oregon State University, 1994.
Area of Study: Toxicology

BA, University of California, 1987.
Area of Study: Biology

Associate Professor, University of Northern Colorado
Biological Sciences (2007 – Present)

Areas of Interest

My research interests are to understand the effects of naturally occurring and man-made chemicals on immunity, development, and homeostasis. Specific chemicals of interest are halogenated aromatic hydrocarbons, pesticides, ethanol, and botanical dietary supplements. These compounds are thought to impact health and development through direct mechanisms, such as altered gene expression, or indirectly through alteration of hormone levels and other pathways. The focus of my laboratory is to investigate mechanisms of toxicity and regulation at the organismal, cellular, and molecular levels with the ultimate aim to improve human and animal health.

Mucosal immunology

I am studying regulation of mucosal immunity by the aryl hydrocarbon receptor. The primary focus is humoral immunity and differential regulation in male versus female mice.

• Foxx CL, Nagy MR, King AE, Albin D, DeKrey GK (2022) TCDD exposure alters fecal IgA concentrations in male and female mice. BMC Pharmacol Toxicol 23, 25. https://doi.org/10.1186/s40360-022-00563-9
• Hufford KM, Weaver OD, Young NM, King AE, DeKrey GK (2021) Flow Cytometry for Identification of PRDM1-eYFP Transgenic Mice. Ursidae: The Undergraduate Research Journal at the University of Northern Colorado: Vol. 10 : No. 1 , Article 3. https://digscholarship.unco.edu/urj/vol10/iss1/3
• Ramos S, DeKrey GK. Does TCDD Exposure Alter ß7-Integrin Expression on Mouse B Cells? Ursidae: The Undergraduate Research Journal at the University of Northern Colorado (2019): 7(2): Article 8. https://digscholarship.unco.edu/urj/vol7/iss2/8
• Sazhnev V, DeKrey GK. The growth and infectivity of Leishmania major is not altered by in vitro exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. BMC Res Notes (2018) 11:642. doi: 10.1186/s13104-018-3759-x.
• Terry AI, Benitez-Kruidenier S, DeKrey GK. Effects of endosulfan isomers on cytokine and nitric oxide production by differentially activated RAW 264.7 cells. Toxicology Reports (2018) Mar 7; 5:396-400. doi: 10.1016/j.toxrep.2018.03.006. PMID: 29765866.
• Worley SL, Vaughn BJ, Terry AI, Gardiner CS, DeKrey GK. Time- and dose-dependent effects of ethanol on mouse embryonic stem cells. Reproductive Toxicology (2015) Nov; 57:157-64.
• DeKrey GK, Teagarden RE, Lenberg JL, RG Titus. 2,3,7,8-Tetrachlorodibenzo-p-dioxin slows the progression of experimental cutaneous leishmaniasis in susceptible BALB/c and SCID mice. PLOS One (2013), 8(10):e76259.
• Peichoto ME, Tavares FL, DeKrey GK, Mackessy SP. Comparative studies of the effects of venoms from five rear-fanged snake species on the growth of Leishmania major. Toxicon (2011), 58(1): 28-34.
• Casabar, RCT, PC Das, GK DeKrey, CS Gardiner, Y Cao, RL Rose, and AD Wallace. Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor. Toxicology and Applied Pharmacology (2010), 245 (3): 335-343.
• Bowers, OJ, KB Sommersted, RT Sowell, GE Boling, WH Hanneman, RG Titus, GK DeKrey. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) reduces Leishmania major burdens in C57Bl/6 Mice. American Journal of Tropical Medicine and Hygiene (2006), 75: 749-752.
• Hausburg, MA, GK DeKrey, JJ Salmen, MR Palic, CS Gardiner. Effects of paraquat on development of preimplantation embryos in vivo and in vitro. Reproductive Toxicology (2005), 20: 239-246.
• DeKrey, GK, J Jones, ML Mbow, CI Brodskyn, RG Titus. B cells are required for delayed type hypersensitivity-like pathology after secondary infection with Leishmania major in resistant C57B1/6 mice. Journal of Tropical Medicine and Hygiene (2003), 69: 481-483.
• Rogers, K, GK DeKrey, ML Mbow, RD Gillespie, CI Brodskyn, RG Titus. Type 1 and type 2 responses to Leishmania major. FEMS Microbiology Letters (2002), 10360: 1-7.
• Mbow, ML, GK DeKrey, RG Titus. Leishmania major induces differential expression of costimulatory molecules on mouse epidermal cells. European Journal of Immunology (2001), 31(5): 1400-9.
• Titus, RG, GK DeKrey, M Suares, R Morris. Interleukin-6-deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease. Infection and Immunity (2001), 69: 5189-5192.
• Brodskyn, CI, GK DeKrey, RG Titus, Influence of costimulatory molecules on the immune response to Leishmania major by human cells in vitro. Infection and Immunity (2001), 69(2): 665-72.
• DeKrey, GK, RG Titus. A method for isolation and analysis of leucocytic cells from leishmanial ear lesions in mice. Journal of Immunological Methods (1999), 228(1-2): 1-11.
• Lima, HC, GK DeKrey, RG Titus. Leishmania braziliensis: Resolution of infection with this parasite confers complete protection to a subsequent challenge with L. major in BALB/c mice. Memórias do Instituto Oswaldo Cruz (1999), 94(1): 71-76.
• DeKrey, GK, Lima, HC, RG Titus. Analysis of the immune response of mice to infection with Leishmania braziliensis. Infection and Immunity (1998), 66(2): 827-929.
• Kerkvliet, NI, L Baecher-Steppan, DM Shepherd, JA Oughton, BA Vorderstrasse, GK DeKrey. Inhibition of TC-1 cytokine production, effector cytotoxic T lymphocyte development and alloantibody production by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Journal of Immunology (1996), 157(6): 2310-2319.
• Oughton, JA, CB Pereira, GK DeKrey, JM Collier, AA Frank, NI Kerkvliet. Phenotypic analysis of spleen, thymus, and peripheral blood cells in aged C57Bl/6 mice following long-term exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fundamental and Applied Toxicology (1995), 25(1): 60-69.
• De Krey, GK, NI Kerkvliet. Suppression of cytotoxic T lymphocyte activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin occurs in vivo, but not in vitro, and is independent of corticosterone elevation. Toxicology (1995), 97(1-3): 105-112.
• DeKrey, GK, NI Kerkvliet. Effects of exogenous corticosterone treatment on alloantigen-specific cytotoxic T lymphocyte activity in mice. Journal of Pharmacology and Experimental Therapeutics (1995), 273(2): 823-829.
• De Krey, GK, NC Hollingshead, NI Kerkvliet, BB Smith. Suppression of prolactin and cytotoxic T lymphocyte activity in PCB-treated mice. International Journal of Immunopharmacology (1994), 16(3): 251-257.
• De Krey, GK, LB Baecher-Steppan, JR Fowles, NI Kerkvliet. Polychlorinated biphenyl-induced suppression of cytotoxic T lymphocyte activity: role of prostaglandin-E2. Toxicology Letters (1994), 74(3): 211-220.
• De Krey, GK, L Baecher-Steppan, JA Deyo, BB Smith, NI Kerkvliet. PCB-induced immune suppression: castration, but not adrenalectomy or RU 38486 treatment, partially restores the cytotoxic T lymphocyte response to alloantigen. Journal of Pharmacology and Experimental Therapeutics (1993), 267(1): 308-315.
• Feldkamp, SD, DP Costa, GK DeKrey. Energetics and behavioral effects of net entanglement on juvenile northern fur seals, Callorhinus ursinus. Fishery Bulletin (1988), 87: 85-94.