University of Northern Colorado
School of Biological Sciences
Campus Box 92
Greeley, CO 80639
Postdoctoral: Molecular Immunology, Department of Biology, Virginia Commonwealth University, Richmond, VA
Ph.D.: Anatomy & Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, VA
B.S.: Biology, James Madison University, Harrisonburg, VA
2016-Present; Assistant Professor, University of Northern Colorado
2013-2016; Clark Cox Professor in Science, William Woods University, Fulton, MO
2012-2016; Assistant Professor of Biology, William Woods University
2010-2012; NIH-IRACDA Postdoctoral Fellow, Department of Biology, Virginia Commonwealth
University and the Department of Chemistry, Geology, and Physics, Elizabeth City State
2014-present; Textbook reviewer for Sinauer Associates, Garland Science, and Morton
2014-2016; Biological Sciences Section Chair, Missouri Academy of Science
2014-2016; Reviewer for the Improving Teacher Quality Grants Program, Missouri Department
of Higher Education
2013-2016; Content expert consultant for the Biology Missouri Educator Gateway Assessment,
Missouri Department of Elementary and Secondary Education
2009-present; Reader and judge for the Virginia Academy of Science
Research/Areas of Interest
Chronic inflammation underlies pathologies as seemingly diverse as cancer, allergy,
and a festering wound. My research focuses on discovering the dysfuncitonal molecular
signals and circuitry causing cells to become bad actors, and why some people are
more prone to these problems than others. In the lab we do this by examining signal
transduction in cells differentiated from adult stem cells, particulary mast cells,
macrophages, and different populations of mesenchymal stem cells. We also use in vivo modeling to observe the consequences of targeting certain pathways in inflammatory
diseases. Our ultimate goals are to better understand the diversity of innate and
adaptive immune responses, and contribute knowledge to more individually tailorable
approaches for treatment. Current specific areas of interest include:
- Differential expression of microRNAs during inflammation and in response to immunosuppression
- Investigating potential off-label drug uses and novel compounds for healthful resolution
of inflammatory responses
- Targeting mast cells and/or specific subsets of macrophages during wound healing
- The roles of trefoil factors in tissue remodeling and cancer progression
- Faber TW, Pullen NA, Fernando J, Kolawole EM, McLeod JJA, Taruselli M, Williams K, Rivera K, Barnstein
BO, Conrad DH and Ryan JJ. ADAM10 is Required for SCF-induced Mast Cell Migration.
Cellular Immunology 2014; 290(1): 80-8.
- Morales JK, Saleem SJ, Martin RK, Saunders BL, Barnstein BO, Faber TW, Pullen NA, Kolawole EM, Brooks KB, Norton SK, Sturgill J, Graham L, Bear HD, Urban JF, Lantz
CS, Conrad DH and Ryan JJ. Myeloid Derived Suppressor Cells Enhance Mast Cell Responses
In Vitro and In Vivo. Journal of Leukocyte Biology 2014; 95(4): 643-50.
- Fernando J, Faber T, Pullen NA, Falanga YT, Kolawole M, Oskeritzian C, Barnstein B, Bandara G, Li G, Schwartz LB,
Gurish M, Spiegel S, Strauss D, Conrad D, Bunting K and Ryan JJ. Genotype-dependent
Effects of TGF1 on Mast Cell Function: Targeting the Stat5 Pathway. The Journal of Immunology 2013; 191(9):4505-13.
- Garg K, Pullen NA, Oskeritzian CA, Ryan JJ and Bowlin GL. Macrophage functional polarization (M1/M2)
in response to varying fiber and pore dimensions of electrospun scaffolds. Biomaterials 2013; 34(18):4439-51.
- Pullen NA, Barnstein BO, Falanga YT, Wang Z, Suzuki R, Lama Tamang TD, Khurana MC, Harry EA,
Rivera J, Draber P, Bunting KD, Mizuno K, Wilson BS and Ryan JJ. Novel mechanism for
FceRI-mediated STAT5 tyrosine phosphorylation and the selective influence of STAT5B
over mast cell cytokine production. The Journal of Biological Chemistry 2012; 287(3) 2045-54.
- Pullen NA, Falanga YT, Morales JK, and Ryan JJ. The Fyn-STAT5 pathway: a new frontier in IgE
and IgG-mediated mast cell signaling (peer-reviewed review). Frontiers in Inflammation 2012; 3: 117.
- Falanga YT, Chaimowitz NS, Charles N, Finkelman FD, Pullen NA, Barbour S, Dholaria K, Faber T, Kolawole M, Huang B, Odom S, Rivera J, Carlyon J,
Conrad DH, Spiegel S, Oskeritzian CA, and Ryan JJ. Lyn but not Fyn kinase controls
IgG-Mediated Systemic Anaphylaxis. The Journal of Immunology 2012; 188(9):4360-8.
- Pullen NA, Anand M, Cooper PS and Fillmore HL. Matrix metalloproteinase-1 expression enhances
tumorigenicity as well as tumor-related angiogenesis and is inversely associated with
TIMP-4 expression in a model of glioblastoma. Journal of Neuro-Oncology 2012; 106(3) 461-71.
- Kabolizadeh P, Engelmann BJ, Pullen NA, Ryan JJ, Stewart J, and Farrell NP. Platinum anti-cancer agents and antidepressants.
Desipramine enhances platinum-based cytotoxicity in human colon cancer cells. Journal of Biological Inorganic Chemistry 2012; 17(1) 123-32.
- Pullen NA and Fillmore HL. Induction of matrix metalloproteinase-1 and glioma cell motility
by nitric oxide. Journal of Neuro-Oncology 2010; 96(2):201-9.
- Rife T, Rasoul B, Pullen N, Mitchell D, Grathwol K and Kurth J. The Effect of a Promoter Polymorphism on the
Transcription of Nitric Oxide Synthase I and Its Relevance to Parkinson’s Disease.
Journal of Neuroscience Research 2009; 87(10):2319-25.
- Golding SE, Pullen NA, Lama Tamang T, Hubbard N, and Barbour S. Undergraduate research training blossoms
at VCU: pollinated by students, nurtured by faculty. Featured vignette, CUR Quarterly 2012; 33(1): 31.
Honors and Awards
2016; Undergraduate Faculty Travel Grant (Seattle, WA), American Association of Immunologists
2015; Louis D. Beaumont Dad’s Association Distinguished Professor Award for Excellence
in Teaching, WWU
2015; AAI Undergraduate Science Faculty Program (Long Beach, CA), American Association
2014; Undergraduate Faculty Travel Grant (Pittsburgh, PA), American Association of Immunologists
2013; Clark Cox Distinguished Professor of Science, chair endowed by the Kresge Foundation,
2010; IRACDA Postdoctoral Fellowship, NIGMS, VCU
2008; Jack Denning Burke Award for Excellence in Cell Biology Research, VCU
2007; A.D. Williams Fellowship, VCU