Department of Kinesiology, Nutrition, and Dietetics
College of Natural and Health Sciences
1996 – PhD, University of Arkansas, Fayetteville, AR
1993 – MS, University of Kansas, Lawrence, KS
1991 – BS, Harding University, Searcy, AR
1996 – 1998: Postdoctoral Research Fellow, Thomas Jefferson University , Jefferson Medical College , Philadelphia , PA
1998 – 2004: Assistant Professor of Sport and Exercise Science, University of Northern Colorado , Greeley , CO
2004 – 2009: Associate Professor of Sport and Exercise Science, University of Northern Colorado, Greeley, CO
2009 – Professor of Sport and Exercise Science, University of Northern Colorado, Greeley, CO
2013 – Present; Director, University of Northern Colorado Cancer Rehabilitation Institute, University of Northern Colorado, Greeley, CO
Dr. Hayward is a Professor of Sport and Exercise Science and the Director of the University of Northern Colorado Cancer Rehabilitation Institute (www.unco.edu/unccri). The focus of our work is to improve the quality of life for cancer survivors by providing clinical exercise-based rehabilitation programs, by educating those individuals who provide exercise-based rehabilitation services, and by conducting basic and applied research that advances our understanding of cancer rehabilitation. As the Director of UNCCRI, Dr. Hayward oversees all clinical, educational, and research activities of the Institute.
Patients enrolled in our cancer rehabilitation program serve as subjects in a wide array of research studies conducted by students in our undergraduate and graduate programs at the University of Northern Colorado. Clinical research conducted at UNCCRI utilizes a multidisciplinary approach which focuses primarily on: 1) the physiological adaptations that occur in cancer survivors during exercise training, 2) identifying the exercise intensity, duration, and modality that provides the greatest benefit for cancer survivors, 3) optimizing current techniques involved with exercise assessment and prescription in cancer survivors, and 4) understanding the effects of exercise on biomarkers of prognosis and survival in cancer survivors.
In order to further understand mechanisms that may explain the beneficial effects of exercise in cancer survivors, we utilize tumor-bearing rodent models to study the effects of exercise on various physiological systems with particular interests in the cardiovascular, muscular, and immune systems. Our facilities are equipped with modern wet laboratory equipment necessary to conduct an array of biological experiments including protein analyses, spectrophotometry, and flow cytometry. Our research focuses primarily on: 1) understanding mechanisms by which exercise attenuates chemotherapy-induced toxicities associated with standard cancer treatments such as anthracyclines, 2) the impact of cancer on cardiac, muscular, and immune function and how exercise can mitigate their deleterious effect, 3) how exercise can be used in the rehabilitation of cancer/cachexia-induced cardiac dysfunction, and 4) the interaction of cancer, chemotherapy, and exercise on clinical biomarkers of cancer prognosis and survival.
Rasé VJ, Hayward R, Haughian JM, Pullen NA. Th17, Th22, and Myeloid Derived Suppressor Cell Population Dynamics and Response to IL-6 in 4T1 Mammary Carcinoma. International Journal of Molecular Sciences 23:10299, 2022.
Wood N, Garritson J, Mathias A, Haughian J, Hayward R. Moderate Intensity Endurance and Resistance Exercise Attenuates Cachexia in Tumor-bearing Mice. Anticancer Research 42:397-405, 2022.
Olson TL, Brown JM, Dames KD, Smith JD, Hayward R. Relationships Between Physiological and Psychological Assessment of Cancer-Related Fatigue. International Journal of Exercise Science 15:177-190, 2022.
Harman N, Lazio M, Hayward R. Exercise Training-Induced Adaptations in Lung Cancer Patients Who Have Undergone a Lobectomy. Experimental Gerontology 155:111587, 2021.
Murphy SP, Hayward R, Smith JD. Exercise Training Improves Postural Steadiness in Cancer Survivors Undergoing Chemotherapy. Gait and Posture 87:136-142, 2021.
Smoak P, Harman N, Flores V, Kisiolek J, Pullen NA, Lisano J, Hayward R, Stewart LK. Kefir Is a Viable Exercise Recovery Beverage for Cancer Survivors Enrolled in a Structured Exercise Program. Medicine & Science in Sports & Exercise 53: 2045-2053, 2021.
Smoak P, Flores V, Harman N, Lisano J, Hayward R, Stewart LK. Structured Exercise in Cancer Survivors: Is it Enough for Neural, Mental Health and Well-being? International Journal of Exercise Science 14(3): 162-176, 2021.
Garritson JD, Haughian JM, Pullen NA, Hayward R. Physical activity delays accumulation of immunosuppressive myeloid-derived suppressor cells. PLoS ONE 15(6): e0234548, 2020 doi.org/ 10.1371/journal.pone.0234548, 2020.
Peterson BM, Shackelford DYK, Brown JM, Brenneke AP, Hayward R. Aerobic and Flexibility Training Positively Impacts Physiological, Psychosocial, and Cognitive Function in an Anaplastic Oligodendroglioma Patient: A Case Report. Journal of Rehabilitation Medicine - Clinical Communications 3:1000032, 2020.
Hayward R,Brown JM, Shackelford DYK, Harman N, Lazio M. Enhancing the Utility and Reporting of Real-World Exercise Programs in Cancer Care. Translational Journal of the American College of Sports Medicine 4:194-195, 2019.
Hall SE, Smuder AJ, Hayward R. Effects of Calorie Restriction and Voluntary Exercise on Doxorubicin-Induced Cardiac Dysfunction. Integrative Cancer Therapies 18:1-9, 2019.
Brown JM, Shackelford DYK, Cress M, Hayward R. Evaluation of an Exercise-Based Phase Program as Part of a Standard Care Model for Cancer Survivors. Translational Journal of the American College of Sports Medicine 4:45–54, 2019.
Christensen MA, Smoak P, Lisano JK, Hayward R, Coronado C, Kage K, Shackelford D, and Stewart LK. Cardiorespiratory Fitness, but not Dietary Inflammatory Index, is Related to C-Reactive Protein in Cancer Survivors. Nutrition and Health 25:195–202, 2019.
Schumacher AN, Shackelford DYK, Brown JM, Hayward R. Validation of the Six-Minute Walk Test for Predicting Peak Vo2 in Cancer Survivors. Medicine and Science in Sports and Exercise 51:271–277, 2019.
Stewart LK, Smoak P, Hydock D, Hayward R, O’Brien K, Lisano DJ, Boeneke C, Christensen M, Mathias A. Milk and Kefir Maintain Aspects of Health During Doxorubicin Treatment in Rats. Journal of Dairy Science 102:1910-1917, 2019.
Parry TL, Hayward R. Exercise Protects Against Cancer-Induced Cardiac Cachexia. Medicine and Science in Sports and Exercise 50:1169-1176, 2018.
Pfannenstiel K, Hayward R. Effects of Resistance Exercise Training on Doxorubicin-Induced Cardiotoxicity. Journal of Cardiovascular Pharmacology 71:332–339, 2018.
Repka CP, Hayward R. Effects of an Exercise Intervention on Cancer-Related Fatigue and its Relationship to Markers of Oxidative Stress. Integrative Cancer Therapies 17:503-510, 2018.
Peterson BM, Brown JM, Shackelford DYK, Olson T, Lalonde TL, Hayward R. Cancer Rehabilitation: Impact of Physical Activity on Initial Clinical Assessments. Journal of Clinical Exercise Physiology 7, 1-7, 2018.
Peterson BM, Johnson C, Case K, Shackelford DYK, Brown JM, Lalonde TL, Hayward R. Feasibility of a Combined Aerobic and Cognitive Training Intervention on Cognitive Function in Cancer Survivors: A Pilot Investigation. Pilot and Feasibility Studies 4:50-61, 2018.
Shackelford DYK, Brown JM, Peterson BM, Schaffer J, Hayward R. Validation of the University of Northern Colorado Cancer Rehabilitation Institute Treadmill Protocol. International Journal of Physical Medicine and Rehabilitation 5:437, 2017.
Dunne RF, Mustian KM, Garcia JM, Dale W, Hayward R, Roussel B, Buschmann MM, Caan BJ, Cole C, Fleming FJ, Chakkalakal JV, Linehan DC, Hezel AF, Mohile S G. Research priorities in cancer cachexia: The University of Rochester Cancer Center NCI Community Oncology Research Program Research Base Symposium on Cancer Cachexia and Sarcopenia. Current Opinion in Supportive and Palliative Care 11:278-286, 2017.
Vin-Raviv N, Akinyemiju T, Qingrui M, Sakuja S, Hayward R. Marijuana Use and Inpatient Outcomes among Hospitalized Patients: Analysis of the Nationwide Inpatient Sample Database. Cancer Medicine 6:320-329, 2017.
O’Brien K, Boeneke C, Prinyawiwatkul W, Lisano J, Shackelford D, Reeves K, Christensen M, Hayward R, Carabante KC, Ordonez, Stewart LK. Sensory Analysis of a Kefir Product Designed for Active Cancer Survivors. Journal of Dairy Science 100:4349–4353, 2017.
Repka CP, Hayward R. Oxidative Stress and Fitness Changes in Cancer Patients Following Exercise Training. Medicine and Science in Sport and Exercise 48:607-614, 2016.
Bredahl EC, Pfannenstiel KB, Quinn CJ, Hayward R, Hydock DS. Effects of Exercise on Doxorubicin-Induced Skeletal Muscle Dysfunction. Medicine and Science in Sport and Exercise 48:1468–1473, 2016.
Quinn CJ, Burns PD, Gibson NM, Bashore A, Hayward R, Hydock DS. Effects of Chronic Exercise on Doxorubicin-Induced Thymic Damage. Integrative Cancer Therapies 15:535-541, 2016.
Quinn CJ, Gibson NM, Pfannenstiel KB, Bashore AC, Hayward R, Hydock DS. Effects of exercise on doxorubicin accumulation and multidrug resistance protein expression in striated muscle. Global Journal of Medical Research 16: 11-22, 2016.
Parry TL, Hayward R. Exercise Training Does Not Affect Anthracycline Anti-Tumor Efficacy While Attenuating Cardiac Dysfunction. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 309: R675-R683, 2015.
Lien C-Y, Jensen BT, Hydock DS, Hayward R. Short-Term Exercise Training Attenuates Acute Doxorubicin Cardiotoxicity. Journal of Physiology and Biochemistry 71: 669-678, 2015.
Schneider CM, Repka CP, Brown JM, Lalonde TL, Dallow KT, Barlow CE, Hayward R. Demonstration of the Need for Cardiovascular and Pulmonary Normative Data for Cancer Survivors. International Journal of Sports Medicine 35: 1134–1137, 2014.
Repka CP, Peterson B, Brown JM, Lalonde TL, Schneider CM, Hayward R. Cancer Type Does Not Affect Exercise-Mediated Improvements in Cardiorespiratory Function and Fatigue. Integrative Cancer Therapies 13: 473-481, 2014.
Parry TL, Hydock DS, Jensen BT, Lien C-Y, Schneider CM, HaywardR. Endurance Exercise Attenuates Cardiotoxicity Induced by Androgen Deprivation and Doxorubicin. Canadian Journal of Physiology and Pharmacology 92: 356-362, 2014.