David S. Hydock, Ph.D.

David  S. Hydock, Ph.D.Education

  • 2005 Ph.D., University of Northern Colorado, Greeley, CO
  • 1996 M.A.T., Northern State University, Aberdeen, SD
  • 1995 B.A., Adams State College, Alamosa, CO

Professional Experience

  • 2009-Present Assistant Professor of Sport and Exercise Science, University of Northern Colorado, Greeley, CO
  • 2008-2009 Lecturer of Sport and Exercise Science, University of Northern Colorado, Greeley, CO
  • 2005-2008 Postdoctoral Research Fellow, University of Northern Colorado, Greeley, CO

Research

Our laboratory focuses primarily on investigating the mechanisms behind cancer treatment related cardiovascular and musculoskeletal side effects and how exercise interventions play a part in battling these negative side effects.  We use animal models to analyze the interaction of cancer treatments and exercise on cardiac and skeletal muscle to gain a better understanding of the mechanisms behind cancer treatment toxicities and exercise-induced protection. 

Funding

American Cancer Society, 2012-2015, MRSG-12-179-01-PCSM, “Doxorubicin Treatment and Skeletal Muscle Function: Effects of Exercise”, Principle Investigator: DS Hydock, Mentor: R Hayward

Selected Publications

Gibson NM, Quinn CJ, Pfannenstiel KB, Hydock DS, Hayward R. Effects of Age on Multidrug Resistance Protein Expression and Doxorubicin Accumulation in Cardiac and Skeletal Muscle. Xenobiotica (In Press)

Gibson NM, Greufe SE, Hydock DS, Hayward R. Doxorubicin-induced vascular dysfunction and its attenuation by exercise preconditioning. Journal of Cardiovascular Pharmacology (In Press).

Jensen BT, Lien CY, Hydock DS, Schneider CM, Hayward R. Exercise mitigates cardiac doxorubicin accumulation and preserves function in the rat. Journal of Cardiovascular Pharmacology (In Press).

Hayward R, Hydock DS, Gibson NM, Greufe SE, Bredahl EC, Parry TL. Tissue retention of doxorubicin and its effects on cardiac, smooth, and skeletal muscle function. Journal of Physiology and Biochemistry (In Press).

Hydock DS, Lien CY, Jensen BT, Schneider CM, Hayward R. Switching to a low-fat diet attenuates the intensified doxorubicin cardiotoxicity associated with high-fat feeding. Cancer Chemotherapy and Pharmacology 71: 1551-1560, 2013.

Sato K, Fortenbaugh D, Hydock DS, Heise GD. Comparison of back squat kinematics between barefoot and shoe conditions. International Journal of Sports Science and Coaching 8: 571-578, 2013.

Hayward R, Iwaniec UT, Turner RT, Lien CY, Jensen BT, Hydock DS, Schneider CM. Voluntary wheel running does not protect against
doxorubicin-mediated bone degeneration in the growing Sprague Dawley rat. Journal of Pediatric Hematology and Oncology 35: 144-148, 2013.

Hydock DS, Lien CY, Jensen BT, Parry TL, Schneider CM, Hayward R. Rehabilitative exercise in a rat model of doxorubicin cardiotoxicity. Experimental Biology and Medicine 237: 1483-1492, 2012.

Hayward R, Lien CY, Jensen BT, Hydock DS, Schneider CM. Exercise training mitigates anthracycline-induced chronic cardiotoxicity in a juvenile rat model. Pediatric Blood and Cancer 59: 149-154, 2012.

Sato K, Fortenbaugh D, Hydock DS. Kinematic changes using weightlifting shoes on barbell back squat. Journal of Strength and Conditioning Research 26: 28-33, 2012.

Hydock DS, Parry TL, Jensen BT, Lien CY, Schneider CM, Hayward R. Effects of endurance training on combined goserelin acetate and doxorubicin treatment-induced cardiac dysfunction.  Cancer Chemotherapy and Pharmacology 68: 685-629, 2011.   

Hydock DS, Lien, CY, Jensen, BT, Schneider, CM, Hayward, R. Characterization of the effects of in vivo doxorubicin treatment on skeletal muscle function in the rat. Anticancer Research 31: 2023-2028, 2011.

Hydock DS, Lien, CY, Jensen, BT, Schneider, CM, Hayward, R. Exercise preconditioning provides long-term protection against early chronic doxorubicin cardiotoxicity. Integrative Cancer Therapies 10: 47-57, 2011.

Hydock DS, Wonders KY, Schneider CM, Hayward R. Voluntary wheel running in rats receiving doxorubicin: effects on running activity and cardiac myosin heavy chain. Anticancer Research 29: 4401-4407, 2009.

Wonders KY, Hydock DS, Greufe, S, Schneider, CM, Hayward, R. Endurance training preserves cardiac function in rats receiving doxorubicin and the HER-2 inhibitor GW2974. Cancer Chemotherapy and Pharmacology 64: 1105-1113, 2009.
                             
Hydock DS, Lien CY, Schneider CM, Hayward R. Anandamide  
preserves cardiac function and geometry in an acute doxorubicin
cardiotoxicity rat model. Journal of Cardiovascular Pharmacology and Therapeutics 14: 59-67, 2009.

Hydock DS, Iwaniec UT, Turner RT, Lien CY, Jensen BT, Parry TL, Hayward R. Effects of voluntary wheel running on goserelin acetate-induced bone degeneration. Pathophysiology 15: 253-259, 2008.

Wonders KY, Hydock DS, Schneider, CM, Hayward, R. Acute exercise protects against doxorubicin cardiotoxicity. Integrative Cancer Therapies 7: 147-154, 2008.

Hsieh CC, Sprod, LK, Hydock DS, Carter SD, Hayward R, Schneider CM. Effects of a Supervised Exercise Intervention on Recovery from Treatment Regimens in Breast Cancer Survivors. Oncology Nursing Forum 35: 909-915, 2008.

Hydock DS, Lien CY, Schneider CM, Hayward R.  Exercise preconditioning protects against doxorubicin-induced cardiac dysfunction by preserving myosin heavy chain composition. Medicine and Science in Sports and Exercise 40: 808-817, 2008.

Hydock DS, Lien CY, Schneider CM, Hayward R. The effects of voluntary wheel running on cardiac function and myosin heavy chain in chemically gonadectomized rats. American Journal of Physiology-Heart and Circulatory Physiology 293: H3254-H3264, 2007.

Wonders KY, Hydock DS, Hayward R. Time-course of changes in cardiac function during recovery after acute exercise. Applied Physiology, Nutrition, and Metabolism 32: 1164-1169, 2007.

Hayward R, Hydock DS. Doxorubicin cardiotoxicity in the rat: an in vivo characterization. Journal of the American Association for Laboratory Animal Science 46: 20-32, 2007.

Hydock DS, Wonders KY, Schneider CM, Hayward R. Androgen deprivation therapy and cardiac function: effects of endurance training.  Prostate Cancer and Prostatic Diseases 9: 392-398, 2006.

Chicco A, Hydock DS, Schneider CM, Hayward R. Low intensity exercise training protects against doxorubicin cardiotoxicity.  Journal of Applied Physiology 100: 519-527, 2006.

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