David S. Hydock, Ph.D.

David  S. Hydock, Ph.D.Education

  • 2005 Ph.D., University of Northern Colorado, Greeley, CO
  • 1996 M.A.T., Northern State University, Aberdeen, SD
  • 1995 B.A., Adams State College, Alamosa, CO

Professional Experience

  • 2014-Present Associate Professor of Sport and Exercise Science, University of Northern Colorado, Greeley, CO
  • 2009-2014 Assistant Professor of Sport and Exercise Science, University of Northern Colorado, Greeley, CO
  • 2008-2009 Lecturer of Sport and Exercise Science, University of Northern Colorado, Greeley, CO
  • 2005-2008 Postdoctoral Research Fellow, University of Northern Colorado, Greeley, CO

Research

Our laboratory focuses primarily on investigating the mechanisms behind cancer treatment related cardiovascular and musculoskeletal side effects and how exercise interventions play a part in battling these negative side effects. We use animal models to analyze the interaction of cancer treatments and exercise on cardiac and skeletal muscle to gain a better understanding of the mechanisms behind cancer treatment toxicities and exercise-induced protection.

Funding

American Cancer Society, 2012-2015, MRSG-12-179-01-PCSM, “Doxorubicin Treatment and Skeletal Muscle Function: Effects of Exercise”, Principle Investigator: DS Hydock, Mentor: R Hayward

Recent Publications

Parry TL, Hydock DS, Jensen BT, Lien CY, Schneider CM, Hayward R. Endurance exercise attenuates cardiotoxicity induced by androgen deprivation and doxorubicin.  Canadian Journal of Physiology and Pharmacology 92: 356-362, 2014.

Gibson NM, Quinn CJ, Pfannenstiel KB, Hydock DS, Hayward R. Effects of Age on Multidrug Resistance Protein Expression and Doxorubicin Accumulation in Cardiac and Skeletal Muscle. Xenobiotica 44: 472-479, 2014.

Hydock DS, Parry TL, Wymore JD, Iwaniec UT, Turner RT, Schneider CM, Hayward R. Effects of treadmill training on combined goserelin acetate and doxorubicin-induced osteopenia in female rats. Journal of Musculoskeletal and Neuronal Interactions 14: 10-18, 2014.

Jensen BT, Lien CY, Hydock DS, Schneider CM, Hayward R. Exercise mitigates cardiac doxorubicin accumulation and preserves function in the rat. Journal of Cardiovascular Pharmacology 62: 263-269, 2013.

Hayward R, Hydock DS, Gibson NM, Greufe SE, Bredahl EC, Parry TL. Tissue retention of doxorubicin and its effects on cardiac, smooth, and skeletal muscle function. Journal of Physiology and Biochemistry 69:177-187, 2013.

Gibson NM, Greufe SE, Hydock DS, Hayward R. Doxorubicin-induced vascular dysfunction and its attenuation by exercise preconditioning. Journal of Cardiovascular Pharmacology 62: 355-360, 2013.

Hydock DS, Lien CY, Jensen BT, Schneider CM, Hayward R. Switching to a low-fat diet attenuates the intensified doxorubicin cardiotoxicity associated with high-fat feeding. Cancer Chemotherapy and Pharmacology 71: 1551-1560, 2013.

Sato K, Fortenbaugh D, Hydock DS, Heise GD. Comparison of back squat kinematics between barefoot and shoe conditions. International Journal of Sports Science and Coaching 8: 571-578, 2013.

Hayward R, Iwaniec UT, Turner RT, Lien CY, Jensen BT, Hydock DS, Schneider CM. Voluntary wheel running does not protect against doxorubicin-mediated bone degeneration in the growing Sprague Dawley rat. Journal of Pediatric Hematology and Oncology 35: 144-148, 2013.

Hydock DS, Lien CY, Jensen BT, Parry TL, Schneider CM, Hayward R. Rehabilitative exercise in a rat model of doxorubicin cardiotoxicity. Experimental Biology and Medicine 237: 1483-1492, 2012.

Hayward R, Lien CY, Jensen BT, Hydock DS, Schneider CM. Exercise training mitigates anthracycline-induced chronic cardiotoxicity in a juvenile rat model. Pediatric Blood and Cancer 59: 149-154, 2012.

Sato K, Fortenbaugh D, Hydock DS. Kinematic changes using weightlifting shoes on barbell back squat. Journal of Strength and Conditioning Research 26: 28-33, 2012.

Hydock DS, Parry TL, Jensen BT, Lien CY, Schneider CM, Hayward R. Effects of endurance training on combined goserelin acetate and doxorubicin treatment-induced cardiac dysfunction.  Cancer Chemotherapy and Pharmacology 68: 685-629, 2011.     

Hydock DS, Lien, CY, Jensen, BT, Schneider, CM, Hayward, R. Characterization of the effects of in vivo doxorubicin treatment on skeletal muscle function in the rat. Anticancer Research 31: 2023-2028, 2011.

Hydock DS, Lien, CY, Jensen, BT, Schneider, CM, Hayward, R. Exercise preconditioning provides long-term protection against early chronic doxorubicin cardiotoxicity. Integrative Cancer Therapies 10: 47-57, 2011.

Hydock DS, Wonders KY, Schneider CM, Hayward R. Voluntary wheel running in rats receiving doxorubicin: effects on running activity and cardiac myosin heavy chain. Anticancer Research 29: 4401-4407, 2009.

Wonders KY, Hydock DS, Greufe, S, Schneider, CM, Hayward, R. Endurance training preserves cardiac function in rats receiving doxorubicin and the HER-2 inhibitor GW2974. Cancer Chemotherapy and Pharmacology 64: 1105-1113, 2009.

Hydock DS, Lien CY, Schneider CM, Hayward R. Anandamide preserves cardiac function and geometry in an acute doxorubicin cardiotoxicity rat model. Journal of Cardiovascular Pharmacology and Therapeutics 14: 59-67, 2009.

Recent Presentations

Hydock DS, Bredahl EC, Gibson NM, Quinn CJ, Hayward R. Correlations between skeletal muscle and cardiac function in exercised and sedentary rats receiving doxorubicin. Poster Presentation, American College of Sports Medicine National Meeting, Orlando, FL, 2014.

Quinn CJ, Elzaidi NM, Gibson NM, Bredahl EC, Hayward R, Hydock DS. Skeletal muscle SERCA expression following doxorubicin treatment: effects of exercise. Poster Presentation, American College of Sports Medicine National Meeting, Orlando, FL, 2014.

Bredahl EC, Hydock DS. The effects of creatine incubation on doxorubicin-induced muscle dysfunction. Poster Presentation, American College of Sports Medicine National Meeting, Orlando, FL, 2014.

Parry TL, Hydock DS, Schneider CM, Hayward R. Effect of exercise training on tumor growth and cardiac function in the rat cancer model. Poster Presentation, American College of Sports Medicine National Meeting, Orlando, FL, 2014.

Hydock DS, Bredahl EC, Gibson, NM, Quinn, CJ, Hayward R. Differential effects of endurance training and resistance training on doxorubicin-induced skeletal muscle dysfunction. Poster Presentation, Experimental Biology Meeting, San Diego, 2014.

Quinn C, Gibson N, Bashore A, Bredahl E, Hayward R, Hydock D. Protective effect of chronic exercise against doxorubicin exposure in the rat thymus. Poster Presentation, Experimental Biology Meeting, San Diego, 2014.

Pfannenstiel K, Gibson NM, Quinn CJ, Hydock DS, Hayward R. Aging down-regulates skeletal muscle multidrug resistance proteins and increases intramuscular doxorubicin accumulation. Poster Presentation, American College of Sports Medicine National Meeting, Indianapolis, IN, 2013.

Parry TL, Greufe SE, Gibson NM, Hydock DS, Schneider CM, Hayward R. Cardiac dysfunction in the tumor bearing rat. Poster Presentation, American College of Sports Medicine National Meeting, Indianapolis, IN, 2013.

Bredahl EC, Pfannenstiel KB, Greufe SE, Gibson NM, Quinn CJ, Schneider CM, Hayward R, Hydock DS. Effects of a resistance training model on doxorubicin-induced muscle dysfunction in the rat. Poster Presentation, American College of Sports Medicine National Meeting, Indianapolis, IN, 2013.

Greufe SE, Gibson NM, Frank AJ, Hydock DS, Schneider CM, Hayward R. Calorie restriction and voluntary exercise extend life span of rats treated with doxorubicin. Poster Presentation, American College of Sports Medicine National Meeting, Indianapolis, IN, 2013.

Gibson NM, Burns PD, Hydock DS, Schneider CM, Hayward R. Juvenile doxorubicin exposure increases cardiac progenitor cell expression in late-onset cardiotoxicities. Poster Presentation, American College of Sports Medicine National Meeting, Indianapolis, IN, 2013.

Hydock DS, Bredahl E, Gibson N, Quinn C, Schneider CM, Hayward R. Endurance exercise and doxorubicin-induced skeletal muscle dysfunction. Poster Presentation, Experimental Biology Meeting, Boston, MA, 2013.

Quinn C, Gibson N, Bredahl E, Schneider C, Hayward R, Hydock D. Intramuscular doxorubicin accumulation and skeletal muscle fatigue: effects of prior exercise. Poster Presentation, Experimental Biology Meeting, Boston, MA, 2013.

Greufe SE, Gibson NM, Hydock DS, Schneider CM, Hayward R. Combined effects of streptozotocin and doxorubicin on cardiac function in rats. Poster Presentation, Experimental Biology Meeting, Boston, MA, 2013.

Gibson NM, Lien CY, Jensen BT, Hydock DS, Hayward R. A rat model of doxorubicin-induced late-onset cardiotoxicity. Poster Presentation, Experimental Biology Meeting, Boston, MA, 2013.

Gibson NM, Pfannenstiel K, Quinn CJ, Hydock DS, Hayward R. Aging downregulates MRPs and increases cardiac doxorubicin accumulation.  Poster Presentation, Experimental Biology Meeting, Boston, MA, 2013.

Shell