Reid Hayward, Ph.D.

Education

• 1996 Ph.D., University of Arkansas , Fayetteville , AR
• 1993 M.S., University of Kansas , Lawrence , KS
• 1991 B.S., Harding University , Searcy , AR

Professional Experience

• 1996 - 1998 Postdoctoral Research Fellow, Thomas Jefferson University , Jefferson Medical College , Philadelphia , PA
• 1998 - 2004 Assistant Professor of Sport and Exercise Science, University of Northern Colorado , Greeley , CO
• 2004 - present Associate Professor of Sport and Exercise Science, University of Northern Colorado, Greeley, CO

Research

The primary focus of our laboratory is the use of pharmacological and non-pharmacological (physical activity) interventions to attenuate the deleterious cardiovascular side effects of chemotherapy. We use animal models of chemotherapy-induced organ toxicity to examine the benefits of specific drugs and exercise in alleviating the deleterious side effects of cancer treatments. Our laboratory uses modern physiological, biochemical, and histological techniques to assess the degree of protection provided by treatment interventions.

In addition to our work with chemotherapy toxicities, our laboratory investigates the influence of acute and chronic exercise on ischemia-reperfusion injury. These studies examine the effects of different exercise modalities on ischemia-reperfusion injury, particularly in the heart, blood vessels, and intestines.

Invited Presentations

Grand Rounds, St. Jude Children's Hospital, Memphis, TN. This presentation can be viewed at https://www.cure4kids.org/public/863

Funding

American Cancer Society, 2004 – 2008, RSG-04-259-01-CCE, "Exercise Training and Doxorubicin-Induced Cardiotoxicity", Principle Investigator: R Hayward

National Institutes of Health, 2007 – 2009, 1R21CA123507-01A1, “Exercise and the Attenuation of Chronic Doxorubicin Cardiotoxicity”, Principle Investigator: R Hayward

Selected Publications

Hydock DS, Iwaniec UT, Turner RT, Lien CY, Jensen BT, Parry TL, Schneider CM, Hayward R. Effects of Voluntary Wheel Running on Goserelin Acetate-Induced Bone Degeneration. Pathophysiology (in press).

Hydock DS, Lien C-Y, Schneider CM, Hayward R.  Exercise Preconditioning Protects Against Doxorubicin-Induced Cardiac Dysfunction. Medicine and Science in Sports and Exercise 40: 808-817, 2008.

Hsieh CC, Sprod LK, Hydock DS, Carter SD, Hayward R, Schneider CM. Effects of a Supervised Exercise Intervention on Recovery from Treatment Regimens in Breast Cancer Survivors. Oncology Nursing Forum (in press).

Hydock DS, Lien C-Y, Schneider CM, Hayward R.  Effects of Voluntary Wheel Running on Cardiac Function and Myosin Heavy Chain in Chemically Gonadectomized Rats. American Journal of Physiology: Heart and Circulatory Physiology 293: H3254-H3264, 2007.

Schneider CM, Hsieh CC, Sprod LK, Carter SD, Hayward R. Cancer Treatment-Induced Alterations in Muscular Fitness and Quality of Life: The Role of Exercise Training. Annals of Oncology 18: 1957-1962, 2007.

Wonders KY, Hydock DS, Hayward R. Time-course of Changes in Cardiac Function During Recovery After Acute Exercise.  Applied Physiology, Nutrition, and Metabolism 32: 1164-1169, 2007.

Hayward R, Hydock DS. Doxorubicin Cardiotoxicity in the Rat: An In Vivo Characterization.  Journal of the American Association for Laboratory Animal Science 46: 20-32, 2007.

Schneider CM, Hsieh CC, Sprod LK, Carter SD, Hayward R. The Effects of Supervised Exercise Training on Cardiopulmonary Function and Fatigue in Breast Cancer Survivors During and Following Treatment. Cancer 110 918-25, 2007.

Schneider CM, Hsieh CC, Sprod LK, Carter SD, Hayward R. Exercise Training Manages Cardiopulmonary Function and Fatigue During and Following Cancer Treatment in Male Cancer Survivors. Integrative Cancer Therapies 6: 235-41, 2007.

Hydock DS, Wonders KY, Schneider CM, Hayward R. Androgen Deprivation Therapy and Cardiac Function: Effects of Endurance Training. Prostate Cancer and Prostatic Disease 9: 392-398, 2006.

Chicco A, Schneider CM, Hayward R. Low intensity exercise training protects against doxorubicin cardiotoxicity. Journal Applied Physiology 100: 519-527, 2006.

Chicco A, Hydock DS, Schneider CM, Hayward R. Exercise training attenuates acute doxorubicin-induced cardiac dysfunction. Journal of Cardiovascular Pharmacology 47: 181-188, 2006.

Chicco A, Turner R, McCarty H, Westerlind K, Hayward R. Resistance exercise training reduces ethanol-induced oxidative stress. European Journal of Cardiovascular and Pulmonary Rehabilitation 13: 74-79, 2006.

Chicco A, Schneider CM, Hayward R. Voluntary exercise protects against doxorubicin cardiotoxicity in the isolated perfused rat heart.  American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology 289: R424-R431, 2005.

Hayward R , Ruangthai R, Schneider CM, McCarty H, Hyslop R, Strange R, Westerlind K. Training Enhances Vascular Relaxation Following Chemotherapy-Induced Vasoconstriction. Medicine and Science in Sports and Exercise 36: 428-434, 2004.

Hayward R , Ruangthai R, Schneider CM, Karnilaw P, Chicco A, McCarty H, Strange R, Westerlind K. Attenuation of homocysteine-induced endothelial dysfunction by exercise training. Pathophysiology 9: 207-214, 2003.

Carter SD, Drum SN, Hayward R , Schneider CM. A Case Study: Prescriptive Exercise Intervention After Bilateral Mastectomies. Integrative Cancer Therapies 2: 34-38, 2003.

Hayward R , Ferrington DA, Kochanowski LA, Miller LM, Jaworsky GM, Schneider CM. Effects of dietary protein on serum and muscle enzyme activity following exercise-induced muscle injury. Medicine and Science in Sports and Exercise 31: 414-420, 1999.

Hayward R , Lefer AM. Administration of polymerized bovine hemoglobin improves survival in a rat model of traumatic shock. Methods and Findings in Experimental and Clinical Pharmacology 21: 427-433, 1999.

Hayward R , Lefer AM. Acute mesenteric ischemia and reperfusion: Protective effects of recombinant soluble P-selectin glycoprotein ligand-1. Shock 12: 201-207, 1999.

Lefer AM, Campbell B, Shin YK, Scalia R, Hayward R , Lefer DJ. Simvastatin preserves the ischemic-reperfused myocardium in normocholesterolemic rat hearts. Circulation 100: 178-184, 1999.

Hayward R , Campbell B, Shin Y, Scalia R, Lefer AM. Recombinant soluble P-selectin glycoprotein ligand-1 protects against myocardial ischemic reperfusion injury in cats. Cardiovascular Research 41: 65-76, 1999.

Hayward R , Lefer AM. Time course of endothelial-neutrophil interaction in splanchnic ischemia-reperfusion. American Journal of Physiology 275: H2080-H2086, 1998.

Hayward R , Nossuli TO, Scalia R, Lefer AM. Time course of intercellular adhesion molecule-1 upregulation following endotoxin administration. Sepsis 2: 171-175, 1998.

Scalia R, Hayward R , Armstead VE, Minchenko AG, Lefer AM. Effect of recombinant soluble P-selectin glycoprotein ligand-1 on leukocyte-endothelium interaction in vivo. Role in rat traumatic shock. Circulation Research 84: 93-102, 1998.

Hayward R , Lefer AM. L-Arginine attenuates endothelial dysfunction and prolongs survival in rats subjected to traumatic shock. Endothelium 6: 71-19, 1998.

Hayward R , Lefer AM. Beneficial effects of LEX-032, a recombinant serpin, following splanchnic ischemia and reperfusion. Cardiovascular Pathobiology 2: 191-198, 1998.

Hayward R , Scalia R, Hopper B, Appell JZ, Lefer AM. Cellular mechanisms of heparinase III protection in rat traumatic shock. American Journal of Physiology 275: H23-H30, 1998.

Nossuli TO, Hayward R , Scalia R, Lefer AM. Mechanisms of cardioprotection by peroxynitrite in myocardial ischemia-reperfusion injury. American Journal of Physiology 275: H509-H519, 1998.

Hayward R , Balog JM, Schneider CM. Response of serum indicators of myocardial infarction following exercise-induced muscle injury. American Journal of Emergency Medicine 16: 1-8, 1998.

Hayward R , Nossuli TO, Lefer AM. Heparinase III exerts endothelial and cardioprotective effects in feline myocardial ischemia-reperfusion injury. Journal of Pharmacology and Experimental Therapeutics 283:1032-1038, 1997.

Hayward R , Nossuli TO, Scalia R, Lefer AM. Cardioprotective effects of interleukin-10 in murine myocardial ischemia-reperfusion. European Journal of Pharmacology 334:157-163, 1997.

Nossuli TO, Hayward R , Scalia R, AM Lefer. Peroxynitrite reduces myocardial infarct size and preserves coronary endothelium following ischemia and reperfusion in cats. Circulation 96: 2317-2324, 1997.

Armstead VE, Minchenko AG, Schuhl RA, Hayward R , Nossuli TO, Lefer AM. Regulation of P-selectin expression in human endothelial cells by nitric oxide. American Journal of Physiology 273: H740-H746, 1997.

Lefer DJ, Scalia R, Campbell B, Nossuli TO, Hayward R , Salamon M, Grayson J, Lefer AM. Peroxynitrite inhibits leukocyte-endothelial cell interactions and protects against ischemia-reperfusion injury in rats. Journal of Clinical Investigation 99: 684-691, 1997.

Book Chapter

Lefer AM, Hayward R . The Role of Nitric Oxide in Ischemia-Reperfusion. In Contemporary Cardiology, vol 4: Nitric Oxide in the Cardiovascular System . Eds. Loscalzo J, Vita JA. Humana Press Inc., Totowa NJ , 2000.