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Michael Mosher

Michael Mosher

Professor of Chemistry; Manager of Brewing Laboratory Science Program

Chemistry and Biochemistry

Contact Information

Phone
970-351-3257
Fax
970-351-2533
Office
ROSS 3590
Mailing Address
University of Northern Colorado

Campus Box 98
Greeley, CO 80639

Education

Dipl. Brew. - Institute of Brewing and Distilling (UK)
Ph.D. (Organic Chemistry) - Texas Tech University, Lubbock TX
M.S. (Organic Chemistry) - Dartmouth College, Hanover NH
B.S. (Chemistry-ACS approved) - University of Idaho, Moscow ID

Research/Areas of Interest

Novel Routes to 2-Isoxazolines and Related Heterocycles

ISO-1, an inhibitor of the proinflammatory cytokine MIF, has been shown to exhibit preventative properties toward Type 1 Diabetes in transgenic mice. We have shown that this compound, and derivatives, can be prepared by the intra-molecular cyclization of a beta,gamma-unsaturated oxime. The reaction utilizes a palladium(II) catalyst to effect the cyclization, and depending upon the specific ligands employed, can result in modest stereocontrol of the reaction. Recent studies in our laboratory have shown that palladium(0) can mediate a tandem intra-molecular cyclization / aryl coupling.

Hydroxylamine Intercalators

In other work, our group is exploring the intercalative properties of O-substituted N-acridinyl hydroxylamines. These compounds are prepared by coupling the O-substituted hydroxylamine with 9-chloroacridine. The results of an initial study indicate that these compounds are effective DNA intercalators with biological activity (as measured by MTT assay). Further work in this area will involve exploration of the kinetics of hydrolysis of these compounds, evaluation of the specific interactions during intercalation, and modification of the O-substituted compounds to enhance biological activity.

Brewing Science

In addition to our work with heterocyclic chemistry, we have begun exploring two major areas of research in beer brewing. The first of these projects involves the exploration of the mechanism of hop acid isomerization. Initial work in this area indicates that the isomerization is magnesium catalyzed. The second of the projects involves the use of spectroscopic techniques for the analysis of components in beer. For example, we have shown that %ABV can be rapidly analyzed by using ATR.

Publications/Creative Works

Recent Publications