Gregory K. DeKrey

Gregory DeKrey

Associate Professor

  • Postdoctoral training: Molecular Toxicology, Colorado State University, Fort Collins, CO (2000-2001)
  • Postdoctoral training: Immunology, Colorado State University, Fort Collins, CO (1995-2000)
  • Postdoctoral training: Cell Biology, Oregon State University, Corvallis, OR (1994-1995)
  • Ph.D.: Toxicology, Oregon State University, Corvallis, OR (1994)
  • B.A.: Biology, University of California, Santa Cruz, CA (1987)

Contact information


Courses taught | Research interests | Grants, awards, and professional honors | Peer-reviewed publications | Review articles | Recently presented papers

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Courses taught

  • BIO 102 (Success in Biology I)
  • BIO 101L (Biological Perspectives Lab)
  • BIO 110 (Principles of Biology)
  • BIO 210 (Cell Biology)
  • BIO 211 (Applications of Cell Biology)
  • BIO 350 (Human Physiology)
  • BIO 381 (Principles of Immunology)
  • BIO 450L (Cell Physiology Lab)
  • BIO 476/576 (Pharmacology)
  • BIO 547 (Immunology and Disease)
  • BIO 556 (Current Topics in Biomedical Research)
  • BIO 591 (Biology Roundtable)

Course web site: http://www.unco.edu/nhs/biology/faculty_staff/dekrey/courses/index.html

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Research interests

My research interests are to understand the effects of naturally occurring and man-made chemicals on immunity, development, and homeostasis. Specific chemicals of interest are halogenated aromatic hydrocarbons, pesticides, ethanol, and botanical dietary supplements. These compounds are thought to impact health and development through direct mechanisms, such as altered gene expression, or indirectly through alteration of hormone levels and other pathways. The focus of my laboratory is to investigate mechanisms of toxicity at the organismal, cellular, and molecular levels with the ultimate aim to improve human and animal health.

Current research projects in my laboratory include:

  • Explaining the mechanisms of altered host resistance to disease and inflammatory responses following exposure to environmental toxicants and model compounds
  • Explaining the mechanisms of altered embryonic stem cell development following exposure to environmental toxicants and model compounds

Laboratory web site: http://www.unco.edu/nhs/biology/faculty_staff/dekrey/lab/index.htm

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Grants, awards and professional honors

External grant awards

  • 2007 -- National Science Foundation, STEP-Type I grant, "Strategies to Enhance Recruitment and Retention of Biology Majors at the University of Northern Colorado" ($749,670) -- co-PI.
  • 2006 -- U.S. Department of Education, Graduate Assistance in Areas of National Need grant, "GAANN -- Improving doctoral education in biology at UNC" ($380,016) -- co-PI.
  • 2001 -- Postdoctoral Individual National Research Service Award, National Institute of Alcohol Abuse and Alcoholism, "Ethanol and gene expression" ($106,000) -- award declined.

Internal grant awards

  • 2009 -- University of Northern Colorado, Faculty Research and Publications Board grant, "Platelet-parasite interactions and severity of disease in leishmaniasis." ($5600).
  • 2008 -- University of Northern Colorado, Research Enhancement Award grant, "Purchase of a flow cytometer" ($22,700).
  • 2005 -- University of Northern Colorado, Faculty Research and Publications Board grant, "Exploring ethanol-modulated gene expression in embryos -- a genomics approach" ($2500).
  • 2005 -- University of Northern Colorado, Summer Faculty Research Fellowship.
  • 2005 -- University of Northern Colorado, Summer Graduate Research Assistantship.
  • 2004 -- University of Northern Colorado, Faculty Research Publications Board grant, "Is the West Nile virus killing Colorado's bats?" ($2500).
  • 2004 -- University of Northern Colorado, Summer Faculty Research Fellowship.
  • 2003 -- University of Northern Colorado, Faculty Publications Research Board grant, "Mechanisms of Herb-Drug Interactions" ($2500).
  • 2003 -- University of Northern Colorado, Summer Graduate Research Assistantship.
  • 2003 -- University of Northern Colorado, Summer Faculty Research Fellowship.
  • 2002 -- University of Northern Colorado, Faculty Publications and Research Board grant, "Chemical Intervention to Reduce the Severity to Leishmanial Disease" ($3500).
  • 1999 -- Colorado State University, College of Veterinary Medicine and Biomedical Sciences, College Research Council grant, "Effects of TCDD on antigen-presenting cell function" ($10,000).

Honors

  • 2008 -- Faculty Research Mentor of the Year, Undergraduate Level, NHS, UNC
  • 2006 -- Outstanding Professor Award, Delta Zeta Sorority, University of Northern Colorado
  • 2004 -- Graduate Faculty Status, Doctoral Endorsement, University of Northern Colorado
  • 2000 -- Postdoctoral Training Fellowship National Institute of Environmental Health Sciences
  • 1990 -- Graduate Student Presentation Award, Society of Toxicology
  • 1988 -- Graduate Training Fellowship, National Institute of Environmental Health Sciences
  • 1986 -- Delfasus Award for Undergraduate Research University of California, Santa Cruz

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Peer-reviewed research publications

Green = undergraduate student; Red = graduate student.

  1. DeKrey GK, Teagarden RE, Lenberg JL, RG Titus. 2,3,7,8-Tetrachlorodibenzo-p-dioxin slows the progression of experimental cutaneous leishmaniasis in susceptible BALB/c and SCID mice. PLOS One (2013), 8(10):e76259.
  2. Peichoto ME, Tavares FL, DeKrey GK, Mackessy SP. Comparative studies of the effects of venoms from five rear-fanged snake species on the growth of Leishmania major. Toxicon (2011), 58(1): 28-34.
  3. Casabar, RCT, PC Das, GK DeKrey, CS Gardiner, Y Cao, RL Rose, and AD Wallace. Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor. Toxicology and Applied Pharmacology (2010), 245 (3): 335-343.
  4. Bowers, OJ, KB Sommersted, RT Sowell, GE Boling, WH Hanneman, RG Titus, GK DeKrey. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) reduces Leishmania major burdens in C57Bl/6 Mice. American Journal of Tropical Medicine and Hygiene (2006), 75: 749-752.
  5. Hausburg, MA, GK DeKrey, JJ Salmen, MR Palic, CS Gardiner. Effects of paraquat on development of preimplantation embryos in vivo and in vitro. Reproductive Toxicology (2005), 20: 239-246.
  6. DeKrey, GK, J Jones, ML Mbow, CI Brodskyn, RG Titus. B cells are required for delayed type hypersensitivity-like pathology after secondary infection with Leishmania major in resistant C57B1/6 mice. Journal of Tropical Medicine and Hygiene (2003), 69: 481-483.
  7. Mbow, ML, GK DeKrey, RG Titus. Leishmania major induces differential expression of costimulatory molecules on mouse epidermal cells. European Journal of Immunology (2001), 31(5): 1400-9.
  8. Titus, RG, GK DeKrey, M Suares, R Morris. Interleukin-6-deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease. Infection and Immunity (2001), 69: 5189-5192.
  9. Brodskyn, CI, GK DeKrey, RG Titus, Influence of costimulatory molecules on the immune response to Leishmania major by human cells in vitro. Infection and Immunity (2001), 69(2): 665-72.
  10. DeKrey, GK, RG Titus. A method for isolation and analysis of leucocytic cells from leishmanial ear lesions in mice. Journal of Immunological Methods (1999), 228(1-2): 1-11.
  11. Lima, HC, GK DeKrey, RG Titus. Leishmania braziliensis: Resolution of infection with this parasite confers complete protection to a subsequent challenge with L. major in BALB/c mice. Memórias do Instituto Oswaldo Cruz (1999), 94(1): 71-76.
  12. DeKrey, GK, Lima, HC, RG Titus. Analysis of the immune response of mice to infection with Leishmania braziliensis. Infection and Immunity (1998), 66(2): 827-929.
  13. Kerkvliet, NI, L Baecher-Steppan, DM Shepherd, JA Oughton, BA Vorderstrasse, GK DeKrey. Inhibition of TC-1 cytokine production, effector cytotoxic T lymphocyte development and alloantibody production by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Journal of Immunology (1996), 157(6): 2310-2319.
  14. Oughton, JA, CB Pereira, GK DeKrey, JM Collier, AA Frank, NI Kerkvliet. Phenotypic analysis of spleen, thymus, and peripheral blood cells in aged C57Bl/6 mice following long-term exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fundamental and Applied Toxicology (1995), 25(1): 60-69.
  15. De Krey, GK, NI Kerkvliet. Suppression of cytotoxic T lymphocyte activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin occurs in vivo, but not in vitro, and is independent of corticosterone elevation. Toxicology (1995), 97(1-3): 105-112.
  16. DeKrey, GK, NI Kerkvliet. Effects of exogenous corticosterone treatment on alloantigen-specific cytotoxic T lymphocyte activity in mice. Journal of Pharmacology and Experimental Therapeutics (1995), 273(2): 823-829.
  17. De Krey, GK, NC Hollingshead, NI Kerkvliet, BB Smith. Suppression of prolactin and cytotoxic T lymphocyte activity in PCB-treated mice. International Journal of Immunopharmacology (1994), 16(3): 251-257.
  18. De Krey, GK, LB Baecher-Steppan, JR Fowles, NI Kerkvliet. Polychlorinated biphenyl-induced suppression of cytotoxic T lymphocyte activity: role of prostaglandin-E2. Toxicology Letters (1994), 74(3): 211-220.
  19. De Krey, GK, L Baecher-Steppan, JA Deyo, BB Smith, NI Kerkvliet. PCB-induced immune suppression: castration, but not adrenalectomy or RU 38486 treatment, partially restores the cytotoxic T lymphocyte response to alloantigen. Journal of Pharmacology and Experimental Therapeutics (1993), 267(1): 308-315.
  20. Feldkamp, SD, DP Costa, GK DeKrey. Energetics and behavioral effects of net entanglement on juvenile northern fur seals, Callorhinus ursinus. Fishery Bulletin (1988), 87: 85-94.

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Peer-Reviewed Review Articles

  1. Rogers, K, GK DeKrey, ML Mbow, RD Gillespie, CI Brodskyn, RG Titus. Type 1 and type 2 responses to Leishmania major. FEMS Microbiology Letters (2002), 10360: 1-7.

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Recently presented papers and posters

Green = undergraduate student; Red = graduate student.

  • Teagarden RE, Lenberg JL, Dunn AR, DeKrey GK (2013) 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) reduces Leishmania major burdens in mice but not in macrophages in vitro. Presented at the Society of Toxicology annual meeting, San Antonio, Texas, USA.
  • Peichoto ME, Tavares FL, Jones SLW, DeKrey GK, Mackessy SP (2012) Comparative study of the in vitro cytotoxic activity of two rear-fanged snake venoms agains 3T3 fibroblasts. Presented at the annual meeting of the Brazilian Society of Pharmacology and Experimental Therapeutics, Brazil.
  • Rogers CE, Bupp MG, K Unyoung, DeKrey G, Stranford S, Medh RD, Tomich G (2012) Successful integration of practical flow cytometric experience into undergraduate education. Journal of Immunology, 186, 51.4. Presented at the annual meeting of the American Association of Immunologists, San Francisco, USA.
  • Peichoto ME, Tavares FL, DeKrey GK, Mackessy SP (2010) Enzymatic and antileishmanial activities of five rear-fanged snake venoms. Presented at the International Union of Toxicology meeting, Barcelona, Spain.
  • Worley SL, Gardiner CS, DeKrey GK (2010) Ethanol causes disregulation of mouse embryonic stem cell development. Presented at the Society of Toxicology annual meeting.
  • Benitez-Kruidenier SL, Fuchs FM, DeKrey GK (2010) Endosulfan-a enhances LPS-stimulated cytokine production in RAW 264.7 cells. Presented at the Society of Toxicology annual meeting.
  • Bonney MG, Lively EL, Gardiner CS, DeKrey GK (2010) St. John's wort reduces tribromoethanol-induced sleep times in human-SXR transgenic mice. Presented at the Society of Toxicology annual meeting.
  • Gardiner, CS, RA Adams, GK DeKrey, R Reinsvold (2009) Increasing Student Graduation in the Biological Sciences. Presented at the annual meeting of STEP awardees, National Science Foundation, Washington, DC.
  • Gardiner, CS, RA Adams, GK DeKrey, R Reinsvold (2008) Establishment of the BIOTA program for Enhancing Recruitment and Retention of Biology Majors at the University of Northern Colorado. Presented at the STEP awardees meeting, National Science Foundation, Washington, DC.
  • EA Lively, NL Schmidt, RCT Casabar, AD Wallace, CS Gardiner, GK DeKrey (2007) Endosulfan-a induces CYP2B6 and CYP3A4 by activating the pregnane X receptor. FASEB J, 21:886.16. Presented at the Federation of American Societies for Experimental Biology annual meeting.
  • RCT Casabar, PC Das, GK DeKrey, CS Gardiner, E Hodgson, RL Rose, AD Wallace (2007) Endosulfan-alpha induces CYP2B6 and CYP3A4 by activation the pregnane X receptor. The Toxicologist, 96, Number S-1. Presented at the Society of Toxicology annual meeting.
  • Gardiner, CS, RA Adams, GK DeKrey, R Reinsvold (2007) Increasing student graduation in the biological sciences. Presented at the STEP awardees meeting, National Science Foundation, Washington, DC.
  • KB Sommersted, GK DeKrey (2006) Reduced parasite burdens are not correlated with TNF levels in Leishmania major-infected TCDD-treated mice. The Toxicologist, 90(1): 53, Poster #259. Society of Toxicology annual meeting.
  • SE Lacher, LM Oko, AC Protain, HJ Protain, CS Gardiner, GK DeKrey (2006) St. John's wort reduces tribromoethanol-induced sleep times in human SXR-transgenic mice. The Toxicologist, 9(1): 375,, Poster #1828. Society of Toxicology annual meeting.
  • DeKrey, GK, RA Adams (2005) West Nile virus infection in wild bats of Colorado. American Association of Immunologists, Annual Meeting.
  • Boling, GE, KB Sommersted, OJ Bowers, RT Sowell, SM Reis, RG Titus, GK DeKrey (2005) TCDD-enhanced resistance to Leishmania major infection correlates with increased expression of inducible nitric oxide synthase (iNOS) in C57B1/6 mice. American Society for Pharmacology and Experimental Therapeutics, Annual Meeting.
  • DeKrey, GK (2005) Leishmaniasis in TCDD-Treated Mice. Eastern Oregon University, Department of Biology.
  • DeKrey, GK (2005) Leishmaniasis in TCDD-Treated Mice. California Polytechnic University, San Louis Obispo, Department of Biological Sciences.
  • DeKrey, GK, OJ Bowers, RT Sowell, GE Boling, RG Titus (2004) TCDD reduces Leishmania major burdens in mice when given before or after infection. American Society for Pharmacology and Experimental Therapeutics, Annual Meeting.
  • DeKrey, GK (2004) Experimental Cutaneous Leishmaniasis in TCDD-Treated Mice. University of Montana, Division of Biological Sciences.
  • Protain AC, Protain HJ, Palic MR, DeKrey GK, Gardiner CS (2003) St. John's Wort Reduces Tribromoethanol-Induced Sleep Times in Mice. Society of Toxicology, Annual Meeting.
  • DeKrey GK, Bridges J, Notyce D, Hanneman WH, Titus RG (2002) IL-13 Expression is Increased by TCDD in Leishmania-infected Mice. American Association of Immunologists, Annual Meeting.
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