Carole M. Schneider, Ph.D.

Carole M. Schneider, Ph.D.Education

  • 1986 Ph.D., University of Minnesota, Minneapolis, MN
  • 1982 M.S., Iowa State University, Ames, IA
  • 1972 B.S., Briar Cliff College, Sioux City, IA

Professional Experience

  • 1992 - Present Professor of Sport and Exercise Science, University of Northern Colorado, Greeley , CO
  • 1996 - Present Director, Rocky Mountain Cancer Rehabilitation Institute, University of Northern Colorado, Greeley, CO
  • 1988-1992 Assistant Professor, University of Kansas, Lawrence, Kansas
  • 1987-1988 Assistant Professor, Baylor College of Medicine, Houston, Texas

Research

The primary focus of our laboratory is the use of pharmacological and non-pharmacological (physical activity) interventions to attenuate the deleterious cardiovascular side effects of chemotherapy in human and animal models. We use human cancer survivors to determine the effects of exercise on cancer treatment related toxicities and symptoms. We use animal models of chemotherapy-induced organ toxicity to examine the benefits of specific drugs and exercise in alleviating the deleterious side effects of cancer treatments. Our laboratory uses modern physiological, biochemical, and histological techniques to assess the degree of protection provided by treatment interventions.

Selected Publications

  1. Hydock DS , Lien C-Y , Jensen BT , Parry TL , Schneider CM, Hayward R. Rehabilitative Exercise in a Rat Model of Doxorubicin Cardiotoxicity. Experimental Biology and Medicine (in press).
  2. Hayward R, Iwaniec U, Turner RT, Lien C-Y, Jensen BT, Hydock DS, Schneider CM. Voluntary Wheel Running in Growing Rats Does Not Protect Against Doxorubicin-Induced Osteopenia. Journal of Pediatric Oncology & Hematology (in press).
  3. Hayward R, Lien C-Y, Jensen BT, Hydock DS, Schneider CM. Exercise Training Mitigates Anthracycline-Induced Chronic Cardiotoxicity in a Juvenile Rat Model. Pediatric Blood & Cancer 59: 149-154, 2012.
  4. Hydock DS, Parry T, Jensen B, Lien C-Y, Schneider CM, Hayward R. Effects of Endurance Training on Combined Goserelin Acetate and Doxorubicin Treatment-Induced Cardiac Dysfunction. Cancer Chemotherapy and Pharmacology 68: 685-692, 2011.
  5. Hydock DS, Lien C-Y, Jensen BT, Schneider CM, Hayward R.  Characterization of the Effect of In Vivo Doxorubicin Treatment on Skeletal Muscle Function in the Rat.  Anticancer Research 31:2023-2028, 2011.
  6. Hydock DS, Lien CY, Jensen BT, Schneider CM, Hayward R. Exercise Preconditioning Provides Long-Term Protection Against Early Chronic Doxorubicin Cardiotoxicity. Integrative Cancer Therapies 10:47-57, 2011.
  7. Sprod LK, Hsieh CC, Hayward R, Schneider CM.  Three vs. Six Months of Exercise Training in Cancer Survivors.  Breast Cancer Research and Treatment 121:412-419, 2010. Hydock DS, Schneider CM, Hayward R. Voluntary Wheel Running in Rats Receiving Doxorubicin: Effects on Running Activity and Cardiac Myosin Heavy Chain. Anticancer Research 29: 4401-4407, 2009.
  8. Wonders KY, Hydock DS, Greufe SE, Schneider CM, Hayward R. Endurance Exercise Training Preserves Cardiac Function in Rats Receiving Doxorubicin and the HER-2 Inhibitor GW2974. Cancer Chemotherapy and Pharmacology 64:1105-1113, 2009.
  9. Hydock DS, Iwaniec UT, Turner RT, Lien CY, Jensen BT, Parry TL, Schneider CM, Hayward R. Effects of Voluntary Wheel Running on Goserelin Acetate-Induced Bone Degeneration. Pathophysiology 15: 253-259, 2008.
  10. Wonders KY, Hydock DS, Schneider CM, Hayward R. Acute Exercise Protects Against Doxorubicin Cardiotoxicity. Integrative Cancer Therapies 7: 147-154, 2008.
  11. Hydock DS, Lien C-Y, Schneider CM, Hayward R.  Exercise Preconditioning Protects Against Doxorubicin-Induced Cardiac Dysfunction. Medicine and Science in Sports and Exercise 40: 808-817, 2008.
  12. Hsieh CC, Sprod LK, Hydock DS, Carter SD, Hayward R, Schneider CM. Effects of a Supervised Exercise Intervention on Recovery from Treatment Regimens in Breast Cancer Survivors. Oncology Nursing Forum 35: 909-915, 2008.
  13. Hydock DS, Lien C-Y, Schneider CM, Hayward R.  Effects of Voluntary Wheel Running on Cardiac Function and Myosin Heavy Chain in Chemically Gonadectomized Rats. American Journal of Physiology: Heart and Circulatory Physiology 293: H3254-H3264, 2007.
  14. Schneider CM, Hsieh CC, Sprod LK, Carter SD, Hayward R. Cancer Treatment-Induced Alterations in Muscular Fitness and Quality of Life: The Role of Exercise Training. Annals of Oncology 18: 1957-1962, 2007.
  15. Schneider, C.S., Hsieh, C.C., Sprod, L.K., Carter, S.D. and Hayward, R.  Effects of Supervised Exercise Training on Cardiopulmonary Function and Fatigue in Breast Cancer Survivors During and After Treatment.  Cancer 110:918-925, 2007. (Summary on BreastCancer.Net News)
  16. Schneider, C.S., Hsieh, C.C., Sprod, L.K., Carter, S.D. and Hayward, R.  Exercise Training Manages Cardiopulmonary Function and Fatigue During and Following Cancer Treatment in Male Cancer Survivors.  Integrative Cancer Therapies 6(3):235-241, 2007.
  17. Hydock, D.S., Wonders, K.Y., Schneider, C.M. and Hayward, R.  Androgen Deprivation Therapy and Cardiac Function: Effects of endurance training.  Prostate Cancer and Prostatic Disease 9:392-398, 2006.
  18. Chicco A, Schneider CM, Hayward R. Low intensity exercise training protects against doxorubicin cardiotoxicity. Journal Applied Physiology 100: 519-527, 2006.
  19. Chicco A, Hydock DS, Schneider CM, Hayward R. Exercise training attenuates acute doxorubicin-induced cardiac dysfunction. Journal of Cardiovascular Pharmacology 47: 181-188, 2006.
  20. Chicco A, Schneider CM, Hayward R. Voluntary exercise protects against doxorubicin cardiotoxicity in the isolated perfused rat heart.  American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology 289: R424-R431, 2005.
  21. Hayward R , Ruangthai R, Schneider CM, McCarty H, Hyslop R, Strange R, Westerlind K. Training Enhances Vascular Relaxation Following Chemotherapy-Induced Vasoconstriction. Medicine and Science in Sports and Exercise 36: 428-434, 2004.
  22. Schneider, C.M, C.A. Dennehy, and S.D. Carter. Exercise and Cancer Recovery. 1st edition, Illinois: Human Kinetics, 2003.
  23. Carter SD, Drum SN, Hayward R, Schneider CM. A Case Study: Prescriptive Exercise Intervention After Bilateral Mastectomies. Integrative Cancer Therapies 2: 34-38, 2003.
  24. Schneider, C.M., C.A. Dennehy, M. Roozeboom, & S.D. Carter. A Model Program: Exercise Invervention for Cancer Rehabilitation. Intergrative Cancer Therapies, 1(1):76-82, 2002.
  25. Hayward R, Ferrington DA, Kochanowski LA, Miller LM, Jaworsky GM, Schneider CM. Effects of dietary protein on serum and muscle enzyme activity following exercise-induced muscle injury. Medicine and Science in Sports and Exercise 31: 414-420, 1999.
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