David S. Hydock, Ph.D.

David  S. Hydock, Ph.D.Education

  • 2005 Ph.D., University of Northern Colorado, Greeley, CO
  • 1996 M.A.T., Northern State University, Aberdeen, SD
  • 1995 B.A., Adams State College, Alamosa, CO

Professional Experience

  • 2014-Present Associate Professor of Sport and Exercise Science, University of Northern Colorado, Greeley, CO
  • 2009-2014 Assistant Professor of Sport and Exercise Science, University of Northern Colorado, Greeley, CO
  • 2008-2009 Lecturer of Sport and Exercise Science, University of Northern Colorado, Greeley, CO
  • 2005-2008 Postdoctoral Research Fellow, University of Northern Colorado, Greeley, CO

Research

Our laboratory focuses primarily on investigating the mechanisms behind cancer treatment related cardiovascular and musculoskeletal side effects and how exercise interventions play a part in battling these negative side effects. We use animal models to analyze the interaction of cancer treatments and exercise on cardiac and skeletal muscle to gain a better understanding of the mechanisms behind cancer treatment toxicities and exercise-induced protection.

Funding

American Cancer Society, 2012-2015, MRSG-12-179-01-PCSM, “Doxorubicin Treatment and Skeletal Muscle Function: Effects of Exercise”, Principle Investigator: DS Hydock, Mentor: R Hayward

Recent Publications

Quinn CJ, Burns PD, Gibson NM, Bashore A, Hayward R, Hydock DS. Effects of chronic exercise on doxorubicin-induced thymic damage. Integrative Cancer Therapies (In Press).

Lien CY, Jensen BT, Hydock DS, Hayward R. Short-term exercise attenuates acute doxorubicin cardiotoxicity. Journal of Physiology and Biochemistry 71: 668-79, 2015.

Parry TL, Hydock DS, Jensen BT, Lien CY, Schneider CM, Hayward R. Endurance exercise attenuates cardiotoxicity induced by androgen deprivation and doxorubicin.  Canadian Journal of Physiology and Pharmacology 92: 356-362, 2014.

Gibson NM, Quinn CJ, Pfannenstiel KB, Hydock DS, Hayward R. Effects of Age on Multidrug Resistance Protein Expression and Doxorubicin Accumulation in Cardiac and Skeletal Muscle. Xenobiotica 44: 472-479, 2014.

Hydock DS, Parry TL, Wymore JD, Iwaniec UT, Turner RT, Schneider CM, Hayward R. Effects of treadmill training on combined goserelin acetate and doxorubicin-induced osteopenia in female rats. Journal of Musculoskeletal and Neuronal Interactions 14: 10-18, 2014.

Jensen BT, Lien CY, Hydock DS, Schneider CM, Hayward R. Exercise mitigates cardiac doxorubicin accumulation and preserves function in the rat. Journal of Cardiovascular Pharmacology 62: 263-269, 2013.

Hayward R, Hydock DS, Gibson NM, Greufe SE, Bredahl EC, Parry TL. Tissue retention of doxorubicin and its effects on cardiac, smooth, and skeletal muscle function. Journal of Physiology and Biochemistry 69:177-187, 2013.

Gibson NM, Greufe SE, Hydock DS, Hayward R. Doxorubicin-induced vascular dysfunction and its attenuation by exercise preconditioning. Journal of Cardiovascular Pharmacology 62: 355-360, 2013.

Hydock DS, Lien CY, Jensen BT, Schneider CM, Hayward R. Switching to a low-fat diet attenuates the intensified doxorubicin cardiotoxicity associated with high-fat feeding. Cancer Chemotherapy and Pharmacology 71: 1551-1560, 2013.

Sato K, Fortenbaugh D, Hydock DS, Heise GD. Comparison of back squat kinematics between barefoot and shoe conditions. International Journal of Sports Science and Coaching 8: 571-578, 2013.

Hayward R, Iwaniec UT, Turner RT, Lien CY, Jensen BT, Hydock DS, Schneider CM. Voluntary wheel running does not protect against
doxorubicin-mediated bone degeneration in the growing Sprague Dawley rat. Journal of Pediatric Hematology and Oncology 35: 144-148, 2013.

Hydock DS, Lien CY, Jensen BT, Parry TL, Schneider CM, Hayward R. Rehabilitative exercise in a rat model of doxorubicin cardiotoxicity. Experimental Biology and Medicine 237: 1483-1492, 2012.

Hayward R, Lien CY, Jensen BT, Hydock DS, Schneider CM. Exercise training mitigates anthracycline-induced chronic cardiotoxicity in a juvenile rat model. Pediatric Blood and Cancer 59: 149-154, 2012.

Sato K, Fortenbaugh D, Hydock DS. Kinematic changes using weightlifting shoes on barbell back squat. Journal of Strength and Conditioning Research 26: 28-33, 2012.

Hydock DS, Parry TL, Jensen BT, Lien CY, Schneider CM, Hayward R. Effects of endurance training on combined goserelin acetate and doxorubicin treatment-induced cardiac dysfunction.  Cancer Chemotherapy and Pharmacology 68: 685-629, 2011.

Hydock DS, Lien, CY, Jensen, BT, Schneider, CM, Hayward, R. Characterization of the effects of in vivo doxorubicin treatment on skeletal muscle function in the rat. Anticancer Research 31: 2023-2028, 2011.

Hydock DS, Lien, CY, Jensen, BT, Schneider, CM, Hayward, R. Exercise preconditioning provides long-term protection against early chronic doxorubicin cardiotoxicity. Integrative Cancer Therapies 10: 47-57, 2011.

Recent Presentations with Abstracts

Bredahl EC, Quinn CJ, Hayward R, Hydock DS. The Effects of Exercise on Antioxidants in Doxorubicin Treated Type 2 Muscle. Poster Presentation, American College of Sports Medicine National Meeting, San Diego, CA, 2015. Medicine & Science in Sports & Exercise. 47: S647, 2015.

Hydock DS, Omar A, Bredahl EC, Quinn CJ. In vivo Skeletal Muscle Function and Doxorubicin Treatment in the Rat. Poster Presentation, Experimental Biology Meeting, Boston, MA, 2015. The Journal of the Federation of American Societies for Experimental Biology 29:1055.21, 2015.

Hydock DS, Bredahl EC, Quinn CJ, Hayward R. Protective Effects of Endurance or Resistance Training Exercise on Chemotherapy-Induced Skeletal Muscle Weakness and Fatigue. Poster Presentation, Experimental Biology Meeting, Boston, MA, 2015. The Journal of the Federation of American Societies for Experimental Biology 29:LB660, 2015.

Quinn CJ, Bredahl EC, Hayward R, Hydock DS. Effect of Doxorubicin Treatment on Myogenic Regulatory Factor Protein Expression in Skeletal Muscle. Poster Presentation, Experimental Biology Meeting, Boston, MA, 2015. The Journal of the Federation of American Societies for Experimental Biology 29:826.9, 2015.

Hochberg L, Borges R, Bredahl EC, Quinn, CJ, Hydock DS. Effects of Voluntary Endurance Training on Skeletal Muscle Function During and Following Doxorubicin Treatment. Poster Presentation, Experimental Biology Meeting, Boston, MA, 2015. The Journal of the Federation of American Societies for Experimental Biology 29:1055.26, 2015.

Hydock DS, Bredahl EC, Gibson NM, Quinn CJ, Hayward R. Correlations between skeletal muscle and cardiac function in exercised and sedentary rats receiving doxorubicin. Poster Presentation, American College of Sports Medicine National Meeting, Orlando, FL, 2014. Medicine & Science in Sports & Exercise. 46: S152, 2014.

Quinn CJ, Elzaidi NM, Gibson NM, Bredahl EC, Hayward R, Hydock DS. Skeletal muscle SERCA expression following doxorubicin treatment: effects of exercise. Poster Presentation, American College of Sports Medicine National Meeting, Orlando, FL, 2014. Medicine & Science in Sports & Exercise. 46: S273, 2014.

Bredahl EC, Hydock DS. The effects of creatine incubation on doxorubicin-induced muscle dysfunction. Poster Presentation, American College of Sports Medicine National Meeting, Orlando, FL, 2014. Medicine & Science in Sports & Exercise. 46: S370, 2014.

Parry TL, Hydock DS, Schneider CM, Hayward R. Effect of exercise training on tumor growth and cardiac function in the rat cancer model. Poster Presentation, American College of Sports Medicine National Meeting, Orlando, FL, 2014. Medicine & Science in Sports & Exercise. 46: S511, 2014.

Hydock DS, Bredahl EC, Gibson, NM, Quinn, CJ, Hayward R. Differential effects of endurance training and resistance training on doxorubicin-induced skeletal muscle dysfunction. Poster Presentation, Experimental Biology Meeting, San Diego, CA, 2014. The Journal of the Federation of American Societies for Experimental Biology 28: 884.5, 2014.

Quinn C, Gibson N, Bashore A, Bredahl E, Hayward R, Hydock D. Effect of chronic exercise on doxorubicin-induced thymic damage. Poster Presentation, Experimental Biology Meeting, San Diego, CA, 2014. The Journal of the Federation of American Societies for Experimental Biology 28: 884.4, 2014.

Pfannenstiel K, Gibson NM, Quinn CJ, Hydock DS, Hayward R. Aging down-regulates skeletal muscle multidrug resistance proteins and increases intramuscular doxorubicin accumulation. Poster Presentation, American College of Sports Medicine National Meeting, Indianapolis, IN, 2013. Medicine & Science in Sports & Exercise. 45: S17, 2013.

Parry TL, Greufe SE, Gibson NM, Hydock DS, Schneider CM, Hayward R. Cardiac dysfunction in the tumor bearing rat. Poster Presentation, American College of Sports Medicine National Meeting, Indianapolis, IN, 2013. Medicine & Science in Sports & Exercise. 45: S32, 2013.

Bredahl EC, Pfannenstiel KB, Greufe SE, Gibson NM, Quinn CJ, Schneider CM, Hayward R, Hydock DS. Effects of a resistance training model on doxorubicin-induced muscle dysfunction in the rat. Poster Presentation, American College of Sports Medicine National Meeting, Indianapolis, IN, 2013. Medicine & Science in Sports & Exercise. 45: S150, 2013.

Greufe SE, Gibson NM, Frank AJ, Hydock DS, Schneider CM, Hayward R. Calorie restriction and voluntary exercise extend life span of rats treated with doxorubicin. Poster Presentation, American College of Sports Medicine National Meeting, Indianapolis, IN, 2013. Medicine & Science in Sports & Exercise. 45: S283, 2013.

Gibson NM, Burns PD, Hydock DS, Schneider CM, Hayward R. Juvenile doxorubicin exposure increases cardiac progenitor cell expression in late-onset cardiotoxicities. Poster Presentation, American College of Sports Medicine National Meeting, Indianapolis, IN, 2013. Medicine & Science in Sports & Exercise. 45: S532, 2013.

Hydock DS, Bredahl E, Gibson N, Quinn C, Schneider CM, Hayward R. Endurance exercise and doxorubicin-induced skeletal muscle dysfunction. Poster Presentation, Experimental Biology Meeting, Boston, MA, 2013. The Journal of the Federation of American Societies for Experimental Biology 27: 712.27, 2013.

Quinn C, Gibson N, Bredahl E, Schneider C, Hayward R, Hydock D. Intramuscular doxorubicin accumulation and skeletal muscle fatigue: effects of prior exercise. Poster Presentation, Experimental Biology Meeting, Boston, MA, 2013. The Journal of the Federation of American Societies for Experimental Biology 27: 712.28, 2013.

Greufe SE, Gibson NM, Hydock DS, Schneider CM, Hayward R. Combined effects of streptozotocin and doxorubicin on cardiac function in rats. Poster Presentation, Experimental Biology Meeting, Boston, MA, 2013. The Journal of the Federation of American Societies for Experimental Biology 27: 701.8, 2013.

Gibson NM, Lien CY, Jensen BT, Hydock DS, Hayward R. A rat model of doxorubicin-induced late-onset cardiotoxicity. Poster Presentation, Experimental Biology Meeting, Boston, MA, 2013. The Journal of the Federation of American Societies for Experimental Biology 27: 1126.8, 2013.

Gibson NM, Pfannenstiel K, Quinn CJ, Hydock DS, Hayward R. Aging downregulates MRPs and increases cardiac doxorubicin accumulation.  Poster Presentation, Experimental Biology Meeting, Boston, MA, 2013. The Journal of the Federation of American Societies for Experimental Biology 27: 1194.7, 2013.