Reid Hayward, Ph.D.

Reid Hayward, Ph.D.Education

  • 1996 Ph.D., University of Arkansas , Fayetteville , AR
  • 1993 M.S., University of Kansas , Lawrence , KS
  • 1991 B.S., Harding University , Searcy , AR

Professional Experience

  • 1996 - 1998 Postdoctoral Research Fellow, Thomas Jefferson University , Jefferson Medical College , Philadelphia , PA
  • 1998 - 2004 Assistant Professor of Sport and Exercise Science, University of Northern Colorado , Greeley , CO
  • 2004 - 2009 Associate Professor of Sport and Exercise Science, University of Northern Colorado, Greeley, CO
  • 2009 – Present Professor of Sport and Exercise Science, University of Northern Colorado, Greeley, CO

Research

The primary focus of our laboratory is the use of pharmacological and non-pharmacological (physical activity) interventions to attenuate the deleterious cardiovascular side effects of chemotherapy. We use animal models of chemotherapy-induced organ toxicity to examine the benefits of specific drugs and exercise in alleviating the deleterious side effects of cancer treatments. Our laboratory uses modern physiological, biochemical, and histological techniques to assess the degree of protection provided by treatment interventions.

In addition to our work with chemotherapy toxicities, our laboratory investigates the influence of acute and chronic exercise on ischemia-reperfusion injury. These studies examine the effects of different exercise modalities on ischemia-reperfusion injury, particularly in the heart, blood vessels, and intestines.

Invited Presentations

Funding

  • American Cancer Society, 2004 – 2008, RSG-04-259-01-CCE, "Exercise Training and Doxorubicin-Induced Cardiotoxicity", Principle Investigator: R Hayward
  • National Institutes of Health, 2007 – 2009, 1R21CA123507-01A1, “Exercise and the Attenuation of Chronic Doxorubicin Cardiotoxicity”, Principle Investigator: R Hayward
  • American Cancer Society, 2012-2015, MRSG-12-179-01-PCSM, “Doxorubicin Treatment and Skeletal Muscle Function: Effects of Exercise”, Principle Investigator: DS Hydock, Mentor: R Hayward

Selected Publications

  1. Schneider CM, Repka CP, Brown JM, Lalonde TL, Dallow KT, Barlow CE, Hayward R. Demonstration of the Need for Cardiovascular and Pulmonary Normative Data for Cancer Survivors. International Journal of Sports Medicine (in press).
  2. Repka CP, Peterson B, Brown JM, Lalonde TL, Schneider CM, Hayward R. Cancer Type Does Not Affect Exercise-Mediated Improvements in Cardiorespiratory Function and Fatigue. Integrative Cancer Therapies (in press).
  3. Parry TL, Hydock DS, Jensen BT, Lien C-Y, Schneider CM, Hayward R. Endurance Exercise Attenuates Cardiotoxicity Induced by Androgen Deprivation and Doxorubicin. Canadian Journal of Physiology and Pharmacology 92: 356-362, 2014.
  4. Hydock DS, Parry TL, Wymore JD, Iwaniec UT, Turner RT, Schneider CM, Hayward R. Effects of Treadmill Training on Combined Goserelin Acetate and Doxorubicin-Induced Osteopenia in Female Rats. Journal of Musculoskeletal and Neuronal Interactions 14: 10-18, 2014.
  5. Gibson N, Quinn C, Pfannenstiel K, Hydock D, Hayward R. Effects of Age on Multidrug Resistance Protein Expression and Doxorubicin Accumulation in Cardiac and Skeletal Muscle. Xenobiotica 44: 472-479, 2014.
  6. Schneider CM, Hayward R. Cancer Rehabilitation and Cancer-Related Fatigue. Journal of Clinical Exercise Physiology 2: 1-7, 2013.
  7. Gibson NM, Greufe SE, Hydock DS, Hayward R. Doxorubicin-Induced Vascular Dysfunction and Its Attenuation by Exercise Preconditioning. Journal of Cardiovascular Pharmacology 62:355-360, 2013.
  8. Hayward R, Hydock DS, Gibson N, Greufe S, Bradel E, Parry TL. Tissue Retention of Doxorubicin and its Effects on Cardiac, Smooth, and Skeletal Muscle Function. Journal of Physiology and Biochemistry 69: 177-187, 2013.
  9. Hayward R, Iwaniec U, Turner RT, Lien C-Y, Jensen BT, Hydock DS, Schneider CM. Voluntary Wheel Running in Growing Rats Does Not Protect Against Doxorubicin-Induced Osteopenia. Journal of Pediatric Oncology & Hematology 35: 144-148, 2013.
  10. Jensen BT, Lien C-Y, Hydock DS, Schneider CM, Hayward R. Exercise Mitigates Cardiac Doxorubicin Accumulation and Preserves Function in the Rat. Journal of Cardiovascular Pharmacology 62:263-269, 2013.
  11. Hydock DS, Lien C-Y, Jensen BT, Schneider CM, Hayward R. Switching to a Low-Fat Diet Attenuates the Intensified Doxorubicin Cardiotoxicity Associated with High-Fat Feeding. Cancer Chemotherapy and Pharmacology 71:1551-1560, 2013.
  12. Hydock DS, Lien C-Y, Jensen BT, Parry TL, Schneider CM, Hayward R. Rehabilitative Exercise in a Rat Model of Doxorubicin Cardiotoxicity. Experimental Biology and Medicine 237: 1483-1492, 2012.
  13. Hayward R, Lien C-Y, Jensen BT, Hydock DS, Schneider CM. Exercise Training Mitigates Anthracycline-Induced Chronic Cardiotoxicity in a Juvenile Rat Model. Pediatric Blood & Cancer 59: 149-154, 2012.
  14. Hayward R, Lien C-Y. Echocardiographic Evaluation of Cardiac Structure and Function During Exercise Training in the Developing Sprague-Dawley Rat. Journal of the American Association for Laboratory Animal Science 50:454-461, 2011.
  15. Hydock DS, Parry T, Jensen B, Lien C-Y, Schneider CM, Hayward R. Effects of Endurance Training on Combined Goserelin Acetate and Doxorubicin Treatment-Induced Cardiac Dysfunction. Cancer Chemotherapy and Pharmacology 68: 685-692, 2011.
  16. Hydock DS, Lien C-Y, Jensen BT, Schneider CM, Hayward R. Characterization of the Effect of In Vivo Doxorubicin Treatment on Skeletal Muscle Function in the Rat. Anticancer Research 31: 2023-2028, 2011.
  17. Hydock DS, Lien CY, Jensen BT, Schneider CM, Hayward R. Exercise Preconditioning Provides Long-Term Protection Against Early Chronic Doxorubicin Cardiotoxicity. Integrative Cancer Therapies 10:47-57, 2011.
  18. Sprod LK, Hsieh CC, Hayward R, Schneider CM. Three vs. Six Months of Exercise Training in Cancer Survivors. Breast Cancer Research and Treatment 121:412-419, 2010.
  19. Hydock DS, Schneider CM, Hayward R. Voluntary Wheel Running in Rats Receiving Doxorubicin: Effects on Running Activity and Cardiac Myosin Heavy Chain. Anticancer Research 29: 4401-4407, 2009.
  20. Wonders KY, Hydock DS, Greufe SE, Schneider CM, Hayward R. Endurance Exercise Training Preserves Cardiac Function in Rats Receiving Doxorubicin and the HER-2 Inhibitor GW2974. Cancer Chemotherapy and Pharmacology 64:1105-1113, 2009.
  21. Hydock DS, Lien CY, Hayward R. Anandamide Preserves Cardiac Function and Geometry in an Acute Doxorubicin Cardiotoxicity Rat Model. Journal of Cardiovascular Pharmacology and Therapeutics 14: 59-67, 2009.
  22. Hydock DS, Iwaniec UT, Turner RT, Lien CY, Jensen BT, Parry TL, Schneider CM, Hayward R. Effects of Voluntary Wheel Running on Goserelin Acetate-Induced Bone Degeneration. Pathophysiology 15: 253-259, 2008.
  23. Hsieh CC, Sprod LK, Hydock DS, Carter SD, Hayward R, Schneider CM. Effects of a Supervised Exercise Intervention on Recovery from Treatment Regimens in Breast Cancer Survivors. Oncology Nursing Forum 35: 909-915, 2008.
  24. Wonders KY, Hydock DS, Schneider CM, Hayward R. Acute Exercise Protects Against Doxorubicin Cardiotoxicity. Integrative Cancer Therapies 7: 147-154, 2008.
  25. Hydock DS, Lien C-Y, Schneider CM, Hayward R. Exercise Preconditioning Protects Against Doxorubicin-Induced Cardiac Dysfunction. Medicine and Science in Sports and Exercise 40: 808-817, 2008.
  26. Hydock DS, Lien C-Y, Schneider CM, Hayward R. Effects of Voluntary Wheel Running on Cardiac Function and Myosin Heavy Chain in Chemically Gonadectomized Rats. American Journal of Physiology: Heart and Circulatory Physiology 293: H3254-H3264, 2007.
  27. Schneider CM, Hsieh CC, Sprod LK, Carter SD, Hayward R. Cancer Treatment-Induced Alterations in Muscular Fitness and Quality of Life: The Role of Exercise Training. Annals of Oncology 18: 1957-1962, 2007.
  28. Wonders KY, Hydock DS, Hayward R. Time-course of Changes in Cardiac Function During Recovery After Acute Exercise. Applied Physiology, Nutrition, and Metabolism 32: 1164-1169, 2007.
  29. Hayward R, Hydock DS. Doxorubicin Cardiotoxicity in the Rat: An In Vivo Characterization. Journal of the American Association for Laboratory Animal Science 46: 20-32, 2007.
  30. Schneider CM, Hsieh CC, Sprod LK, Carter SD, Hayward R. The Effects of Supervised Exercise Training on Cardiopulmonary Function and Fatigue in Breast Cancer Survivors During and Following Treatment. Cancer 110 918-25, 2007.
  31. Schneider CM, Hsieh CC, Sprod LK, Carter SD, Hayward R. Exercise Training Manages Cardiopulmonary Function and Fatigue During and Following Cancer Treatment in Male Cancer Survivors. Integrative Cancer Therapies 6: 235-41, 2007.
  32. Hydock DS, Wonders KY, Schneider CM, Hayward R. Androgen Deprivation Therapy and Cardiac Function: Effects of Endurance Training. Prostate Cancer and Prostatic Disease 9: 392-398, 2006.
  33. Chicco A, Schneider CM, Hayward R. Exercise training attenuates acute doxorubicin-induced cardiac dysfunction. Journal of Cardiovascular Pharmacology 47: 181-188, 2006.
  34. Chicco A, Hydock DS, Schneider CM, Hayward R. Low intensity exercise training protects against doxorubicin cardiotoxicity. Journal Applied Physiology 100: 519-527, 2006.
  35. Chicco A, Turner R, McCarty H, Westerlind K, Hayward R. Resistance exercise training reduces ethanol-induced oxidative stress. European Journal of Cardiovascular and Pulmonary Rehabilitation 13: 74-79, 2006.
  36. Chicco A, Schneider CM, Hayward R. Voluntary exercise protects against doxorubicin cardiotoxicity in the isolated perfused rat heart. American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology 289: R424-R431, 2005.
  37. Hayward R, Ruangthai R, Schneider CM, McCarty H, Hyslop R, Strange R, Westerlind K. Training enhances vascular relaxation following chemotherapy-induced vasoconstriction. Medicine and Science in Sports and Exercise 36: 428-434, 2004.
  38. Hayward R, Hutcheson KA, Schneider CM. Influence of acute resistance exercise on cardiac biomarkers in untrained females. Journal of Emergency Medicine 25: 4-9, 2003.
  39. Hayward R, Ruangthai R, Schneider CM, Karnilaw P, Chicco A, McCarty H, Strange R, Westerlind K. Attenuation of homocysteine-induced endothelial dysfunction by exercise training. Pathophysiology 9: 207-214, 2003.
  40. Carter SD, Drum SN, Hayward R, Schneider CM. A case study: Prescriptive exercise intervention after bilateral mastectomies. Integrative Cancer Therapies 2: 34-38, 2003.
  41. Hayward R, Ferrington DA, Kochanowski LA, Miller LM, Jaworsky GM, Schneider CM. Effects of dietary protein on serum and muscle enzyme activity following exercise-induced muscle injury. Medicine and Science in Sports and Exercise 31: 414-420, 1999.
  42. Hayward R, Lefer AM. Administration of polymerized bovine hemoglobin improves survival in a rat model of traumatic shock. Methods and Findings in Experimental and Clinical Pharmacology 21: 427-433, 1999.
  43. Hayward R, Lefer AM. Acute mesenteric ischemia and reperfusion: Protective effects of recombinant soluble P-selectin glycoprotein ligand-1. Shock 12: 201-207, 1999.
  44. Lefer AM, Campbell B, Shin YK, Scalia R, Hayward R, Lefer DJ. Simvastatin preserves the ischemic-reperfused myocardium in normocholesterolemic rat hearts. Circulation 100: 178-184, 1999.
  45. Hayward R, Campbell B, Shin Y, Scalia R, Lefer AM. Recombinant soluble P-selectin glycoprotein ligand-1 protects against myocardial ischemic reperfusion injury in cats. Cardiovascular Research 41: 65-76, 1999.
  46. Scalia R, Hayward R, Armstead VE, Minchenko AG, Lefer AM. Effect of recombinant soluble P-selectin glycoprotein ligand-1 on leukocyte-endothelium interaction in vivo. Role in rat traumatic shock. Circulation Research 84: 93-102, 1999.
  47. Hayward R, Lefer AM. Time course of endothelial-neutrophil interaction in splanchnic ischemia-reperfusion. American Journal of Physiology: Heart and Circulatory Physiology 275: H2080-H2086, 1998.
  48. Hayward R, Nossuli TO, Scalia R, Lefer AM. Time course of intercellular adhesion molecule-1 upregulation following endotoxin administration. Sepsis 2: 171-175, 1998.
  49. Hayward R, Lefer AM. L-Arginine attenuates endothelial dysfunction and prolongs survival in rats subjected to traumatic shock. Endothelium 6: 71-19, 1998.
  50. Hayward R, Lefer AM. Vasculoprotective effects of LEX-032, a novel recombinant serpin, during splanchnic ischemia and reperfusion. Cardiovascular Pathobiology 2: 191-198, 1998.
  51. Hayward R, Scalia R, Hopper B, Appell JZ, Lefer AM. Cellular mechanisms of heparinase III protection in rat traumatic shock. American Journal of Physiology: Heart and Circulatory Physiology 275: H23-H30, 1998.
  52. Nossuli TO, Hayward R, Scalia R, Lefer AM. Mechanisms of cardioprotection by peroxynitrite in myocardial ischemia-reperfusion injury. American Journal of Physiology: Heart and Circulatory Physiology 275: H509-H519, 1998.
  53. Hayward R, Dennehy CA, Rodearmel SJ, Schneider CM. Serum creatine kinase, CK-MB, and perceived soreness following eccentric exercise in oral contraceptive users. Journal of Sports Medicine, Training, and Rehabilitation 8: 193-207, 1998.
  54. Hayward R, Balog JM, Schneider CM. Response of serum indicators of myocardial infarction following exercise-induced muscle injury. American Journal of Emergency Medicine 16: 1-8, 1998.
  55. Hayward R, Nossuli TO, Lefer AM. Heparinase III exerts endothelial and cardioprotective effects in feline myocardial ischemia-reperfusion injury. Journal of Pharmacology and Experimental Therapeutics 283:1032-1038, 1997.
  56. Hayward R, Nossuli TO, Scalia R, Lefer AM. Cardioprotective effects of interleukin-10 in murine myocardial ischemia-reperfusion. European Journal of Pharmacology 334:157-163, 1997.
  57. Nossuli TO, Hayward R, Scalia R, AM Lefer. Peroxynitrite reduces myocardial infarct size and preserves coronary endothelium following ischemia and reperfusion in cats. Circulation 96: 2317-2324, 1997.
  58. Armstead VE, Minchenko AG, Schuhl RA, Hayward R, Nossuli TO, Lefer AM. Regulation of P-selectin expression in human endothelial cells by nitric oxide. American Journal of Physiology: Heart and Circulatory Physiology 273: H740-H746, 1997.
  59. Lefer DJ, Scalia R, Campbell B, Nossuli TO, Hayward R, Salamon M, Grayson J, Lefer AM. Peroxynitrite inhibits leukocyte-endothelial cell interactions and protects against ischemia-reperfusion injury in rats. Journal of Clinical Investigation 99: 684-691, 1997.
  60. Schneider CM, Dennehy CA, Rodearmel SJ, Hayward R. Effects of physical activity on creatine phosphokinase and the isoenzyme creatine kinase MB. Annals of Emergency Medicine 25: 520-524, 1995.

Book Chapter

Schneider CM, Hayward R. Cancer. In Exercise Physiology: From a Cellular to an Integrative Approach.  Eds. Philippe Connes, Olivier Hue, Stéphane Perrey.  IOC Press, 2010.

Lefer AM, Hayward R . The Role of Nitric Oxide in Ischemia-Reperfusion. In Contemporary Cardiology, vol 4: Nitric Oxide in the Cardiovascular System . Eds. Loscalzo J, Vita JA. Humana Press Inc., Totowa NJ , 2000.

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